SLC2A4 Antibody (C-term) [APR10066G]

• Background:

  Tissue Location: Skeletal and cardiac muscles; brown and white fat.

• Synonyms:

  Solute carrier family 2, facilitated glucose transporter member 4, Glucose transporter type 4, insulin-responsive, GLUT-4, SLC2A4, GLUT4

• Gene Name:

  HGNC:11009

• Gene ID:

  6517

• UniProt:

  P14672

• Chromosomal Location:

  Cell membrane {ECO:0000250|UniProtKB:P14142}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P14142} Endomembrane system; Multi-pass membrane protein. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:P14142}. Note=Localizes primarily to the perinuclear region, undergoing continued recycling to the plasma membrane where it is rapidly reinternalized (PubMed:8300557) . The dileucine internalization motif is critical for intracellular sequestration (PubMed:8300557) . Insulin stimulation induces translocation to the cell membrane (By similarity) {ECO:0000250|UniProtKB:P14142, ECO:0000269|PubMed:8300557}

• Applications:

  WB

• Dilution:

  WB--1:1000

• Function:

  Insulin-regulated facilitative glucose transporter, which plays a key role in removal of glucose from circulation. Response to insulin is regulated by its intracellular localization: in the absence of insulin, it is efficiently retained intracellularly within storage compartments in muscle and fat cells. Upon insulin stimulation, translocates from these compartments to the cell surface where it transports glucose from the extracellular milieu into the cell.

• Molecular Weight:

  54787

• Storage Conditions:

  Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

• Overview:

  We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality SLC2A4 Antibody (C-term) [APR10066G].

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/?term=6517

• Uniprot URL:

  https://www.uniprot.org/uniprot/P14672