COL17A1 Antibody (Center) [APR15516G]

• Background:

  Tissue Location: Detected in skin (PubMed:8618013) . In the cornea, it is detected in the epithelial basement membrane, the epithelial cells, and at a lower level in stromal cells (at protein level) (PubMed:25676728) . Stratified squamous epithelia. Found in hemidesmosomes. Expressed in cornea, oral mucosa, esophagus, intestine, kidney collecting ducts, ureter, bladder, urethra and thymus but is absent in lung, blood vessels, skeletal muscle and nerves

• Synonyms:

  Collagen alpha-1 (XVII) chain, 180 kDa bullous pemphigoid antigen 2, Bullous pemphigoid antigen 2, 120 kDa linear IgA disease antigen, 120 kDa linear IgA dermatosis antigen, Linear IgA disease antigen 1, LAD-1, 97 kDa linear IgA disease antigen, 97 kDa linear IgA bullous dermatosis antigen, 97 kDa LAD antigen, 97-LAD, Linear IgA bullous disease antigen of 97 kDa, LABD97, COL17A1, BP180, BPAG2

• Gene Name:

  COL17A1

• Gene ID:

  1308

• UniProt:

  Q9UMD9

• Chromosomal Location:

  Cell junction, hemidesmosome. Membrane; Single- pass type II membrane protein. Note=Localized along the plasma membrane of the hemidesmosome [97 kDa linear IgA disease antigen]: Secreted, extracellular space, extracellular matrix, basement membrane Note=Localized in the lamina lucida beneath the hemidesmosomes

• Applications:

  IHC-P, WB, FC

• Dilution:

  FC--1:25 WB--1:2000

• Form:

  Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

• Function:

  May play a role in the integrity of hemidesmosome and the attachment of basal keratinocytes to the underlying basement membrane.

• Molecular Weight:

  150419

• Storage Conditions:

  Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

• Overview:

  We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality COL17A1 Antibody (Center) [APR15516G].

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/?term=1308

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q9UMD9