ULK3 Antibody (N-term) [AMM08431G]

• Background:

  Tissue Location: Widely expressed. Highest levels observed in fetal brain. In adult tissues, high levels in brain, liver and kidney, moderate levels in testis and adrenal gland and low levels in heart, lung, stomach, thymus, prostate and placenta. In the brain, highest expression in the hippocampus, high levels also detected in the cerebellum, olfactory bulb and optic nerve. In the central nervous system, lowest levels in the spinal cord

• Synonyms:

  Serine/threonine-protein kinase ULK3, Unc-51-like kinase 3, ULK3

• Gene Name:

  ULK3

• Gene ID:

  25989

• UniProt:

  Q6PHR2

• Chromosomal Location:

  Cytoplasm. Note=Localizes to pre-autophagosomal structure during cellular senescence

• Applications:

  WB, IHC-P

• Dilution:

  WB--1:2000

• Form:

  Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

• Function:

  Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy. Acts as a negative regulator of SHH signaling in the absence of SHH ligand: interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3) . Positively regulates SHH signaling in the presence of SHH: dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation. Phosphorylates in vitro GLI2, as well as GLI1 and GLI3, although less efficiently. Also acts as a regulator of autophagy: following cellular senescence, able to induce autophagy.

• Molecular Weight:

  53444

• Storage Conditions:

  Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

• Overview:

  We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality ULK3 Antibody (N-term) [AMM08431G].

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/?term=25989

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q6PHR2