DOK1 Antibody (N-term) [APR07616G]

• Background:

  Tissue Location: Expressed in pancreas, heart, leukocyte and spleen. Expressed in both resting and activated peripheral blood T-cells Expressed in breast cancer.

• Synonyms:

  Docking protein 1, Downstream of tyrosine kinase 1, p62 (dok), pp62, DOK1

• Gene Name:

  DOK1

• Gene ID:

  1796

• UniProt:

  Q99704

• Chromosomal Location:

  [Isoform 1]: Cytoplasm. Nucleus.

• Applications:

  WB, IHC-P

• Dilution:

  WB--1:1000 IHC-P--1:100~500

• Form:

  Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.

• Function:

  DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3.

• Molecular Weight:

  52392

• Storage Conditions:

  Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

• Overview:

  We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality DOK1 Antibody (N-term) [APR07616G].

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/?term=1796

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q99704