CLIC1 Antibody [APG02647G]

• Background:

  Tissue Location: Expression is prominent in heart, placenta, liver, kidney and pancreas.

• Synonyms:

  Chloride intracellular channel protein 1, Chloride channel ABP, Nuclear chloride ion channel 27, NCC27, Regulatory nuclear chloride ion channel protein, hRNCC, CLIC1, G6, NCC27

• Gene Name:

  CLIC1

• Gene ID:

  1192

• UniProt:

  O00299

• Chromosomal Location:

  Nucleus. Nucleus membrane; Single-pass membrane protein. Cytoplasm. Cell membrane; Single-pass membrane protein. Note=Mostly in the nucleus including in the nuclear membrane (PubMed:9139710, PubMed:12681486) . Small amount in the cytoplasm and the plasma membrane (PubMed:9139710) . Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain (PubMed:11940526, PubMed:11551966, PubMed:14613939) .

• Applications:

  IHC-P, WB

• Dilution:

  IHC-P--1:100~500 WB--1:1000

• Form:

  Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

• Function:

  Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Involved in regulation of the cell cycle.

• Molecular Weight:

  26923

• Storage Conditions:

  Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

• Overview:

  We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality CLIC1 Antibody [APG02647G].

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/?term=1192

• Uniprot URL:

  https://www.uniprot.org/uniprot/O00299