CLIC4 Antibody [APG02654G]

• Background:

  Tissue Location: Detected in epithelial cells from colon, esophagus and kidney (at protein level) . Expression is prominent in heart, kidney, placenta and skeletal muscle.

• Synonyms:

  Chloride intracellular channel protein 4, Intracellular chloride ion channel protein p64H1, CLIC4

• Gene Name:

  CLIC4

• Gene ID:

  25932

• UniProt:

  Q9Y696

• Chromosomal Location:

  Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasmic vesicle membrane; Single- pass membrane protein. Nucleus matrix. Cell membrane; Single-pass membrane protein Mitochondrion. Cell junction. Note=Colocalized with AKAP9 at the centrosome and midbody. Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain Present in an intracellular vesicular compartment that likely represent trans-Golgi network vesicles

• Applications:

  WB, IHC-P

• Dilution:

  WB--1:1000 IHC-P--1:100~500

• Form:

  Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

• Function:

  Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Promotes cell-surface expression of HRH3. Has alternate cellular functions like a potential role in angiogenesis or in maintaining apical-basolateral membrane polarity during mitosis and cytokinesis. Could also promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis) .

• Molecular Weight:

  28772

• Storage Conditions:

  Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

• Overview:

  We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality CLIC4 Antibody [APG02654G].

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/?term=25932

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q9Y696