GIT1 Antibody (Center) [APR16145G]

CAT: 0882-APR16145G-01Size: 50 µLDry Ice: NoHazardous: No

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CAT#:0882-APR16145G-01Size:50 µL

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality GIT1 Antibody (Center) [APR16145G].

Synonyms

ARF GTPase-activating protein GIT1, ARF GAP GIT1, Cool-associated and tyrosine-phosphorylated protein 1, CAT-1, CAT1, G protein-coupled receptor kinase-interactor 1, GRK-interacting protein 1, GIT1

Gene Name

GIT1

Gene ID

28964

UniProt

Q9Y2X7

Chromosomal Location

Cytoplasm. Cell junction, synapse. Cell junction, synapse, presynapse {ECO:0000250|UniProtKB:Q9Z272}. Cell junction, synapse, postsynapse {ECO:0000250|UniProtKB:Q9Z272}. Cell junction, synapse, postsynaptic density {ECO:0000250|UniProtKB:Q9Z272}. Cell junction, focal adhesion. Cell projection, lamellipodium. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Note=Cycles between at least 3 distinct intracellular compartments, including focal adhesions, cytosolic complexes, containing at least PXN/paxillin, ARHGEF7 and PAK1, and membrane protrusions. During cell migration, moves from the disassembling adhesions into the cytosol and towards the leading edge. In adherent cells, localizes to adhesions. Recruitment to adhesions may be mediated by RAC and active tyrosine-phosphorylated PXN (PubMed:11896197) . May be present in both excitatory and inhibitory synapses. In hippocampal neurons, recruitment of GIT1 to synapses is regulated by ephrinB activation and ephrinB downstream effector GRB4/NCK2. In hippocampal neurons, partially colocalizes with PCLO (By similarity) . Interaction with GRIN3A limits GIT1 synaptic localization (By similarity) . Localization to the centrosome does not depend upon the presence of gamma-tubulin (PubMed:27012601) {ECO:0000250|UniProtKB:Q9Z272, ECO:0000269|PubMed:11896197, ECO:0000269|PubMed:27012601}

Applications

IHC-P, WB

Dilution

WB--1:2000 IHC-P--1:100~500

Form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Function

2701260123108400109381121189619715923189126955021580019312695502252847833150230219273721

Molecular Weight

84341

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/?term=28964

Uniprot URL

https://www.uniprot.org/uniprot/Q9Y2X7

UniProtKB · Q9Y2X7

ARF GTPase-activating protein GIT1

GIT1_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: Q9Y2X7
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: GIT1
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: ARF GAP GIT1
EC number: —
Processing: —
Secondary accessions: B4DGU9, B4DSV3, Q86SS0, Q9BRJ4

Protein keywords

Coding sequence diversity

Alternative splicing

Domain

ANK repeatCoiled coilRepeatZinc-finger

Cellular component

Cell junctionCell projectionCytoplasmCytoskeletonSynapse

Molecular function

GTPase activation

Ligand

Metal-bindingZinc

PTM

Phosphoprotein

Technical term

Proteomics identificationReference proteome

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