AKT1 Antibody (C-term) [APR07023G]

• Background:

  Tissue Location: Expressed in prostate cancer and levels increase from the normal to the malignant state (at protein level) . Expressed in all human cell types so far analyzed. The Tyr-176 phosphorylated form shows a significant increase in expression in breast cancers during the progressive stages i.e. normal to hyperplasia (ADH), ductal carcinoma in situ (DCIS), invasive ductal carcinoma (IDC) and lymph node metastatic (LNMM) stages.

• Synonyms:

  RAC-alpha serine/threonine-protein kinase, Protein kinase B, PKB, Protein kinase B alpha, PKB alpha, Proto-oncogene c-Akt, RAC-PK-alpha, AKT1, PKB, RAC

• Gene Name:

  AKT1

• Gene ID:

  207

• UniProt:

  P31749

• Chromosomal Location:

  Cytoplasm {ECO:0000250|UniProtKB:P31750}. Nucleus. Cell membrane {ECO:0000250|UniProtKB:P31750}. Note=Nucleus after activation by integrin-linked protein kinase 1 (ILK1) . Nuclear translocation is enhanced by interaction with TCL1A. Phosphorylation on Tyr-176 by TNK2 results in its localization to the cell membrane where it is targeted for further phosphorylations on Thr-308 and Ser-473 leading to its activation and the activated form translocates to the nucleus. Colocalizes with WDFY2 in intracellular vesicles (PubMed:16792529) .

• Applications:

  WB, FC

• Dilution:

  WB--1:1000 FC--1:10~50

• Form:

  Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

• Function:

  15526160118823832162096021432781155261601188238321620960214327811552616011882383216209602143278111994271111542761115427612150915103580751035807510358075982996498299641217633812964941199342211772601620086174202319021959249110576742109269252343117120471940185070421698269916139227206827683232206232228865

• Molecular Weight:

  55686

• Storage Conditions:

  Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

• Overview:

  We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality AKT1 Antibody (C-term) [APR07023G].

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/?term=207

• Uniprot URL:

  https://www.uniprot.org/uniprot/P31749