M Sema5a Antibody [APR12486G]

• Synonyms:

  Semaphorin-5A, Semaphorin-F, Sema F, SEMA5A, SEMAF

• Gene Name:

  SEMA5A

• Gene ID:

  9037

• UniProt:

  Q13591

• Chromosomal Location:

  Membrane; Single-pass type I membrane protein.

• Applications:

  WB

• Dilution:

  WB--1:1000

• Form:

  Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.

• Function:

  Bifunctional axonal guidance cue regulated by sulfated proteoglycans; attractive effects result from interactions with heparan sulfate proteoglycans (HSPGs), while the inhibitory effects depend on interactions with chondroitin sulfate proteoglycans (CSPGs) (By similarity) . Ligand for receptor PLXNB3. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1. May promote angiogenesis by increasing endothelial cell proliferation and migration and inhibiting apoptosis.

• Molecular Weight:

  120615

• Storage Conditions:

  Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

• Overview:

  We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality M Sema5a Antibody [APR12486G].

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/?term=9037

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q13591