PTPRZ1 Antibody (N-term) [APR13029G]

• Background:

  Tissue Location: Specifically expressed in the central nervous system, where it is localized in the Purkinje cell layer of the cerebellum, the dentate gyrus, and the subependymal layer of the anterior horn of the lateral ventricle. Developmentally regulated in the brain.

• Synonyms:

  Receptor-type tyrosine-protein phosphatase zeta, R-PTP-zeta, Protein-tyrosine phosphatase receptor type Z polypeptide 1, Protein-tyrosine phosphatase receptor type Z polypeptide 2, R-PTP-zeta-2, PTPRZ1, HTPZP2, PTPRZ, PTPRZ2, PTPZ

• Gene Name:

  PTPRZ1

• Gene ID:

  5803

• UniProt:

  P23471

• Chromosomal Location:

  [Isoform 1]: Cell membrane; Single-pass type I membrane protein. Secreted. Note=A secreted form is apparently generated by shedding of the extracellular domain

• Applications:

  WB

• Dilution:

  WB--1:1000

• Function:

  Protein tyrosine phosphatase that negatively regulates oligodendrocyte precursor proliferation in the embryonic spinal cord. Required for normal differentiation of the precursor cells into mature, fully myelinating oligodendrocytes. May play a role in protecting oligondendrocytes against apoptosis. May play a role in the establishment of contextual memory, probably via the dephosphorylation of proteins that are part of important signaling cascades (By similarity) .

• Molecular Weight:

  254587

• Storage Conditions:

  Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

• Overview:

  We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality PTPRZ1 Antibody (N-term) [APR13029G].

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/?term=5803

• Uniprot URL:

  https://www.uniprot.org/uniprot/P23471