DMP1 Antibody (N-term) [APR15749G]

• Background:

  Tissue Location: Expressed in tooth particularly in odontoblast, ameloblast and cementoblast

• Synonyms:

  Dentin matrix acidic phosphoprotein 1, DMP-1, Dentin matrix protein 1, DMP1

• Gene Name:

  DMP1

• Gene ID:

  1758

• UniProt:

  Q13316

• Chromosomal Location:

  Nucleus. Cytoplasm. Secreted, extracellular space, extracellular matrix. Note=In proliferating preosteoblasts it is nuclear, during early maturation stage is cytoplasmic and in mature osteoblast localizes in the mineralized matrix. Export from the nucleus of differentiating osteoblast is triggered by the release of calcium from intracellular stores followed by a massive influx of this pool of calcium into the nucleus

• Applications:

  WB

• Dilution:

  WB--1:1000

• Form:

  Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

• Function:

  May have a dual function during osteoblast differentiation. In the nucleus of undifferentiated osteoblasts, unphosphorylated form acts as a transcriptional component for activation of osteoblast- specific genes like osteocalcin. During the osteoblast to osteocyte transition phase it is phosphorylated and exported into the extracellular matrix, where it regulates nucleation of hydroxyapatite.

• Molecular Weight:

  55782

• Storage Conditions:

  Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

• Overview:

  We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality DMP1 Antibody (N-term) [APR15749G].

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/?term=1758

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q13316