DMP1 (NM_001079911) Human Recombinant Protein

• Background:

  Dentin matrix acidic phosphoprotein is an extracellular matrix protein and a member of the small integrin binding ligand N-linked glycoprotein family. This protein, which is critical for proper mineralization of bone and dentin, is present in diverse cells of bone and tooth tissues. The protein contains a large number of acidic domains, multiple phosphorylation sites, a functional arg-gly-asp cell attachment sequence, and a DNA binding domain. In undifferentiated osteoblasts it is primarily a nuclear protein that regulates the expression of osteoblast-specific genes. During osteoblast maturation the protein becomes phosphorylated and is exported to the extracellular matrix, where it orchestrates mineralized matrix formation. Mutations in the gene are known to cause autosomal recessive hypophosphatemia, a disease that manifests as rickets and osteomalacia. The gene structure is conserved in mammals. Two transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

• Synonyms:

  ARHP; ARHR; DMP-1

• Gene ID:

  1758

• UniProt:

  Q13316, Q13316-2

• Accession Number mRNA:

  NM_001079911

• Chromosomal Location:

  4q22.1

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Secreted Protein

• Molecular Weight:

  52.3 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  DMP1

• Species:

  Human

• Protein ID:

  NP_001073380

• Overview:

  Recombinant protein of human dentin matrix acidic phosphoprotein 1 (DMP1), transcript variant 2

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/1758

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q13316

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_001079911

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_001073380