BNIP3 Antibody (BH3 Domain Specific) [APR10804G]

• Synonyms:

  BCL2/adenovirus E1B 19 kDa protein-interacting protein 3, BNIP3, NIP3

• Gene Name:

  BNIP3

• Gene ID:

  664

• UniProt:

  Q12983

• Chromosomal Location:

  Mitochondrion. Mitochondrion outer membrane; Single-pass membrane protein. Note=Coexpression with the EIB 19-kDa protein results in a shift in NIP3 localization pattern to the nuclear envelope. Colocalizes with ACAA2 in the mitochondria. Colocalizes with SPATA18 at the mitochondrion outer membrane

• Applications:

  IF, WB, IHC-P

• Dilution:

  IF--1:500 WB--1:1000 IF--1:50~100 IHC-P--1:100~500

• Form:

  Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

• Function:

  Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. Plays an important role in the calprotectin (S100A8/A9) -induced cell death pathway.

• Molecular Weight:

  27832

• Storage Conditions:

  Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

• Overview:

  We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality BNIP3 Antibody (BH3 Domain Specific) [APR10804G].

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/?term=664

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q12983