CLDN7 Antibody (C-term) [APR15495G]

• Background:

  Tissue Location: Expressed in kidney, lung and prostate. Isoform 1 seems to be predominant, except in some normal prostate samples, where isoform 2 is the major form. Down-regulated in breast cancers, including ductal carcinoma in situ (DCIS), lobular carcinoma in situ (LCIS) and invasive ductal carcinoma (IDC) (at protein level), as well as in several cancer cell lines. Loss of expression correlates with histological grade, occurring predominantly in high-grade lesions

• Synonyms:

  Claudin-7, CLDN-7, CLDN7, CEPTRL2, CPETRL2

• Gene Name:

  CLDN7

• Gene ID:

  1366

• UniProt:

  O95471

• Chromosomal Location:

  Cell membrane; Multi-pass membrane protein. Basolateral cell membrane. Cell junction, tight junction. Note=Co-localizes with EPCAM at the basolateral cell membrane and tight junction

• Applications:

  WB, IHC-P, FC

• Dilution:

  WB--1:1000 IHC-P--1:100~500 FC--1:10~50

• Form:

  Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

• Function:

  Plays a major role in tight junction-specific obliteration of the intercellular space.

• Molecular Weight:

  22418

• Storage Conditions:

  Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

• Overview:

  We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality CLDN7 Antibody (C-term) [APR15495G].

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/?term=1366

• Uniprot URL:

  https://www.uniprot.org/uniprot/O95471