Products for Research Use Only
RegisterLogin

Obexelimab

CAT: 0804-HY-P99761-01Size: 1 mgDry Ice: YesHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-P99761-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Obexelimab (XmAb5871) is a humanized anti-CD19 antibody. Obexelimab works by inhibiting B cell receptor (BCR) mediated calcium influx and promoting the phosphorylation of Fc γ receptor IIb (FcγRIIb), which reduces B cell activation and function, leading to B cell apoptosis. Obexelimab can be used in research for rheumatoid arthritis and systemic lupus erythematosus[1][2][3].
CAS Number
1690307-05-1
Product Name Alternative
XmAb5871
UNSPSC
12352203
Target
Apoptosis; CD19
Type
Inhibitory Antibodies
Related Pathways
Apoptosis; Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/obexelimab.html
Purity
99.99
Solubility
10 mM in DMSO
Smiles
[Obexelimab]
Molecular Weight
(147.24 kDa)
References & Citations
[1]Boyles JS, et al. A nondepleting anti-CD19 antibody impairs B cell function and inhibits autoimmune diseases. JCI Insight. 2023 Jul 10;8 (13) :e166137. |[2]Chu SY, et al. Suppression of rheumatoid arthritis B cells by XmAb5871, an anti-CD19 antibody that coengages B cell antigen receptor complex and Fcγ receptor IIb inhibitory receptor. Arthritis Rheumatol. 2014 May;66 (5) :1153-64. |[3]Horton HM, et al. Antibody-mediated coengagement of FcγRIIb and B cell receptor complex suppresses humoral immunity in systemic lupus erythematosus. J Immunol. 2011 Apr 1;186 (7) :4223-33.
Shipping Conditions
Dry Ice
Storage Conditions
Store at -80°C for 2 years
Scientific Category
Inhibitory Antibodies
Clinical Information
Phase 3

Alternative Products

CatalogName
T81624-01Obexelimab
GTR18333591-01Obexelimab Antibody
592052Obexelimab (CD19)
HB996076-01Research Grade Obexelimab
C00824-1mgObexelimab (Anti-CD19)
E55B0314Obexelimab (Reference antibody)
048287CD19 (obexelimab) discontinued
A138484Obexelimab Biosimilar (Monoclonal, IgG1)
F1171-.1Anti-CD19 Antibody (Obexelimab)
ICH5719-20mgObexelimab Biosimilar - Research Grade

Popular Products