Cyproterone acetate

CAT: 0804-HY-13604-01Size: 250 mgDry Ice: NoHazardous: No
CAT#:0804-HY-13604-01Size:250 mg
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Description
Cyproterone acetate is an anti-androgen (IC50=7.1 nM) and progestogen synthetic steroid. Cyproterone acetate has affinity with progesteron and with glucocorticoidal receptors[1][2].
CAS Number
[427-51-0]
UNSPSC
12352211
Hazard Statement
H312, H332
Target
Androgen Receptor
Type
Reference compound
Related Pathways
Vitamin D Related/Nuclear Receptor
Field of Research
Cancer; Endocrinology
Assay Protocol
https://www.medchemexpress.com/Cyproterone-acetate.html
Concentration
10mM
Purity
99.90
Solubility
DMSO : 33.33 mg/mL (ultrasonic) |Ethanol : 20 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL
Smiles
C[C@]12[C@]3([H])[C@@](C(C=C1C(Cl)=C[C@]4([H])[C@]2([H])CC[C@]5([C@@]4([H])CC[C@@]5(C(C)=O)OC(C)=O)C)=O)([H])C3
Molecular Formula
C24H29ClO4
Molecular Weight
416.94
Precautions
H312, H332
References & Citations
[1]Sonneveld, E., et al., Development of androgen- and estrogen-responsive bioassays, members of a panel of human cell line-based highly selective steroid-responsive bioassays. Toxicol Sci, 2005. 83 (1) : p. 136-48.|[2]Torri V, . Cyproterone acetate in the therapy of prostate carcinoma. Arch Ital Urol Androl. 2005;77 (3) :157-163.|[3]Chen L, et al. Cyproterone acetate enhances TRAIL-induced androgen-independent prostate cancer cell apoptosis via up-regulation of death receptor 5. BMC Cancer. 2017;17 (1) :179. Published 2017 Mar 7.|[4]Migally N. Effect of cyproterone acetate on the structure of the adrenal cortex. Arch Androl. 1979;2 (2) :109-115.|[5]Takiguchi M, et al. Cyproterone acetate induces a cellular tolerance to cadmium in rat liver epithelial cells involving reduced cadmium accumulation. Toxicology. 2001;165 (1) :13-25.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched

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