Cyproterone acetate

• Description :

  Cyproterone acetate is an anti-androgen (IC50=7.1 nM) and progestogen synthetic steroid. Cyproterone acetate has affinity with progesteron and with glucocorticoidal receptors[1][2].

• UNSPSC :

  12352211

• Hazard Statement :

  H312, H332

• Target :

  Androgen Receptor

• Type :

  Reference compound

• Related Pathways :

  Vitamin D Related/Nuclear Receptor

• Field of Research :

  Cancer; Endocrinology

• Assay Protocol :

  https://www.medchemexpress.com/Cyproterone-acetate.html

• Concentration :

  10mM

• Purity :

  99.90

• Solubility :

  DMSO : 33.33 mg/mL (ultrasonic) |Ethanol : 20 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL

• Smiles :

  C[C@]12[C@]3([H])[C@@](C(C=C1C(Cl)=C[C@]4([H])[C@]2([H])CC[C@]5([C@@]4([H])CC[C@@]5(C(C)=O)OC(C)=O)C)=O)([H])C3

• Molecular Formula :

  C24H29ClO4

• Molecular Weight :

  416.94

• Precautions :

  H312, H332

• References & Citations :

  [1]Sonneveld, E., et al., Development of androgen- and estrogen-responsive bioassays, members of a panel of human cell line-based highly selective steroid-responsive bioassays. Toxicol Sci, 2005. 83 (1) : p. 136-48.|[2]Torri V, . Cyproterone acetate in the therapy of prostate carcinoma. Arch Ital Urol Androl. 2005;77 (3) :157-163.|[3]Chen L, et al. Cyproterone acetate enhances TRAIL-induced androgen-independent prostate cancer cell apoptosis via up-regulation of death receptor 5. BMC Cancer. 2017;17 (1) :179. Published 2017 Mar 7.|[4]Migally N. Effect of cyproterone acetate on the structure of the adrenal cortex. Arch Androl. 1979;2 (2) :109-115.|[5]Takiguchi M, et al. Cyproterone acetate induces a cellular tolerance to cadmium in rat liver epithelial cells involving reduced cadmium accumulation. Toxicology. 2001;165 (1) :13-25.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Launched

• CAS Number :

  [427-51-0]