Miltefosine

CAT: 0804-HY-13685-01Size: 100 mgDry Ice: NoHazardous: No
CAT#:0804-HY-13685-01Size:100 mg
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Description
Miltefosine is a broad spectrum antimicrobial, anti-leishmanial, phospholipid agent acting by inhibiting the PI3K/Akt activity[1][2][3][4]. Miltefosine is an inhibitor of CTP-phosphocholine cytidyltransferase (CCT) [5].
CAS Number
[58066-85-6]
Product Name Alternative
HePC; Hexadecyl phosphocholine
UNSPSC
12352211
Hazard Statement
H301, H334
Target
Akt; HIV; Parasite
Type
Reference compound
Related Pathways
Anti-infection; PI3K/Akt/mTOR
Applications
COVID-19-anti-virus
Field of Research
Infection; Cancer
Assay Protocol
https://www.medchemexpress.com/Miltefosine.html
Purity
99.92
Solubility
DMSO : 3.33 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 33.33 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=P(OCC[N+](C)(C)C)(OCCCCCCCCCCCCCCCC)[O-]
Molecular Formula
C21H46NO4P
Molecular Weight
407.57
Precautions
H301, H334
References & Citations
[1]Chugh P, et al. Akt inhibitors as an HIV-1 infected macrophage-specific anti-viral therapy. Retrovirology. 2008 Jan 31;5:11|[2]Uberall F, et al. Hexadecylphosphocholine inhibits inositol phosphate formation and protein kinase C activity. Cancer Res. 1991 Feb 1;51 (3) :807-12.|[3]Bhatt AP, et al. Dual inhibition of PI3K and mTOR inhibits autocrine and paracrine proliferative loops in PI3K/Akt/mTOR-addicted lymphomas. Blood. 2010 Jun 3;115 (22) :4455-63.|[4]Eissa MM, et al. Miltefosine Lipid Nanocapsules for Single Dose Oral Treatment of Schistosomiasis Mansoni: A Preclinical Study. PLoS One. 2015 Nov 17;10 (11) :e0141788|[5]de Freitas-Junior PR, et al. Effects of miltefosine on the proliferation, ultrastructure, and phospholipid composition of Angomonas deanei, a trypanosomatid protozoan that harbors a symbiotic bacterium. FEMS Microbiol Lett. 2012 Aug;333 (2) :129-37.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
HIV-1

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