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Saccharopine

CAT: 0804-HY-W040307Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-W040307Size:1 mg
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Description
Saccharopine (L-Saccharopine), a lysine degradation intermediate, is a mitochondrial toxin. Lysine and α-ketoglutarate are converted into Saccharopine by the lysine-ketoglutarate reductase. Saccharopine is then oxidized to α-aminoapidate semialdehyde and glutamate by the saccharopine dehydrogenase. Saccharopine impairs development by disrupting mitochondrial homeostasis[1][2][3].
CAS Number
997-68-2
Product Name Alternative
L-Saccharopine
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
Endogenous Metabolite
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/saccharopine.html
Purity
97.51
Solubility
DMSO : 8.3 mg/mL (ultrasonic; warming)
Smiles
OC([C@@H](NCCCC[C@H](N)C(O)=O)CCC(O)=O)=O
Molecular Formula
C11H20N2O6
Molecular Weight
276.29
Precautions
H302, H315, H319, H335
References & Citations
[1]Zhou J, et, al. The lysine catabolite saccharopine impairs development by disrupting mitochondrial homeostasis. J Cell Biol. 2019 Feb 4;218 (2) :580-597.|[2]Leandro J, et, al. Saccharopine, a lysine degradation intermediate, is a mitochondrial toxin. J Cell Biol. 2019 Feb 4;218 (2) :391-392.|[3]Papes F, et, al. Lysine degradation through the saccharopine pathway in mammals: involvement of both bifunctional and monofunctional lysine-degrading enzymes in mouse. Biochem J. 1999 Dec 1;344 Pt 2 (Pt 2) :555-63.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Human Endogenous Metabolite

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