Anti-Hu CD49d APC-Cy1537

Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Dry Ice Shipment: No

Alternative Products

Cat	Name
MBS1800310-02	Anti-Hu CD49d APC-Cyanine7
MBS1800310-01	Anti-Hu CD49d APC-Cyanine7
MBS1800308-01	Anti-Hu CD49d FITC
MBS1800309-01	Anti-Hu CD49d PE
MBS1800309-02	Anti-Hu CD49d PE
MBS1800306-02	Anti-Hu CD49d Purified
MBS1800306-01	Anti-Hu CD49d Purified
MBS1800308-02	Anti-Hu CD49d FITC
MBS1800307-01	Anti-Hu CD49d Purified Low Endotoxin
MBS1800307-02	Anti-Hu CD49d Purified Low Endotoxin

CAT:

270-T4-171-T100

Size:

100 Tests

Price:

Ask

For price, please contact [email protected].

Anti-Hu CD49d APC-Cy1537

Background: CD49d / integrin alpha 4, unlike other alpha integrins, neither contains an I-domain, nor undergoes disulfide-linked cleavage. It associates with beta 7 chain to form alpha 4 / beta 7 integrin, and with beta 1 chain (CD29) to form VLA-4 integrin. These complexes are important for lymphocyte migration from circulation into tissue (binding VCAM-1) and homing of T cell subsets to Peyer´s patches (binding MadCAM-1), but VLA-4 is also target for invasive bacteria which contain invasin. CD49d is essential for differentiation and migration of hematopoietic stem cells by their adhesion to bone marrow stromal cells, and provides a costimulatory signal to TCR-CD3 complex by inducing phosphorylation of some focal adhesion proteins.
Specifications: The mouse monoclonal antibody 9F10 recognizes an extracellular epitope of CD49d (alpha 4 integrin), a 145-180 kDa type I transmembrane glycoprotein expressed on B and T cells, monocytes, eosinophils, basophils, NK cells, and dendritic cells, but not platelets.
Certification: RUO
Host: Mouse
Species Reactivity: Sheep, Cat, Horse, Dog, Cow, Non-human primates, Human
Target Antigen: CD49d
Isotype: Igg1 κ
Clone: 9F10
Applications: Flow cytometry: The reagent is designed for analysis of human blood cells using 4 μl reagent / 100 μl of whole blood or 106 cells in a suspension. The content of a vial (0.4 mL) is sufficient for 100 tests.
Validated Applications: FC
Format: APC-Cy1537
Buffer: Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
References & Citations: *Stenner MP, Waschbisch A, Buck D, Doerck S, Einsele H, Toyka KV, Wiendl H: Effects of natalizumab treatment on Foxp3+ T regulatory cells. PLoS One. 2008 Oct 63(10):e3319. , URL: http://www.ncbi.nlm.nih.gov/pubmed/18836525,*Chigaev A, Waller A, Amit O, Halip L, Bologa CG, Sklar LA: Real-time analysis of conformation-sensitive antibody binding provides new insights into integrin conformational regulation. J Biol Chem. 2009 May 22284(21):14337-46, URL: http://www.ncbi.nlm.nih.gov/pubmed/19251697 ,*Schneider-Hohendorf T, Rossaint J, Mohan H, Böning D, Breuer J, Kuhlmann T, Gross CC, Flanagan K, Sorokin L, Vestweber D, Zarbock A, Schwab N, Wiendl H: VLA-4 blockade promotes differential routes into human CNS involving PSGL-1 rolling of T cells and MCAM-adhesion of TH17 cells. J Exp Med. 2014 Aug 25211(9):1833-46., URL: https://pubmed.ncbi.nlm.nih.gov/25135296/,*Yoon SO, Lee IY, Zhang X, Zapata MC, Choi YS: CD9 may contribute to the survival of human germinal center B cells by facilitating the interaction with follicular dendritic cells. FEBS Open Bio. 2014 Apr 134:370-6. , URL: http://www.ncbi.nlm.nih.gov/pubmed/24918051 ,*Zhang XF, Feng MF: Adherence of human monocytes and NK cells to human TNF-alpha-stimulated porcine endothelial cells. Immunol Cell Biol. 2000 Dec78(6):633-40., URL: http://www.ncbi.nlm.nih.gov/pubmed/11114974 ,*Soler D, Chapman T, Yang LL, Wyant T, Egan R, Fedyk ER: The binding specificity and selective antagonism of vedolizumab, an anti-alpha4beta7 integrin therapeutic antibody in development for inflammatory bowel diseases. J Pharmacol Exp Ther. 2009 Sep330(3):864-75., URL: https://pubmed.ncbi.nlm.nih.gov/19509315/,
Storage Conditions: Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Complementary Product Range

Our range of products, including Anti-Hu CD49d APC-Cy1537, falls within the same field of application and can be used across various research projects. These products are carefully selected for their high performance and reliability, supporting the diverse needs of modern laboratories. Whether for ongoing studies or future experiments, they are designed to help researchers achieve their scientific goals. Here are some related products that may be of interest for similar or future applications:

Each item in our collection, is tested for precision and quality, ensuring dependable solutions for your research. As we continue to incorporate the latest advancements, Gentaur ensures that our product range remains relevant and versatile, providing you with the tools needed for both current and future projects.

Find us on

Cat	Name
T4-171-T100	Anti-Hu CD49d APC-Cy1537
T4-306-T100	Anti-Hu CD21 APC-Cy1537
T4-630-T100	Anti-Hu CD62L APC-Cy1537
T4-691-T100	Anti-Hu CD5 APC-Cy1537
T4-160-T100	Anti-Hu CD45 APC-Cy1537
T4-173-T025	Anti-Hu CD3 APC-Cy1537
T4-208-T025	Anti-Hu CD9 APC-Cy1537
T4-209-T100	Anti-Hu CD10 APC-Cy1537
T4-220-T025	Anti-Hu CD43 APC-Cy1537
T4-222-T100	Anti-Hu CD45 APC-Cy1537