Anti-R-RAS2 PE

Anti-R-RAS2 PE

• Background: R-Ras2 / TC21 is the only member of R-Ras family of small GTPases that shows transforming activities similar to H-Ras, N-Ras, and K-Ras, and it is also structurally similar to them. R-Ras2 seems to play an important role in activating signal transduction pathways that control cell proliferation. Its mutations are associated with the growth of certain tumors, but also overexpression of the wild type form of R-Ras2 has been frequently detected in various carcinomas. Pseudogenes of R-Ras2 gene are found on chromosomes 1 and 2. Alternate splicing results in multiple transcript variants.
• Specifications: The mouse monoclonal antibody EM-50 recognizes R-Ras2 / TC21 protein (intracellular antigen) and does not react with R-Ras1, H-Ras, K-Ras, and N-Ras.
• CAS Number: 9007-83-4
• Certification: RUO
• Host: Mouse
• Species Reactivity: Human
• Immunogen: Human TC21
• Target Antigen: R-RAS2
• Isotype: Igg1 κ
• Clone: EM-50
• Applications: Flow cytometry: Recommended dilution: 1-4 μg/mL. Intracellular staining.
• Validated Applications: FC
• Concentration: 0.1 mg/mL
• Format: PE
• Buffer: Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
• Other References: *Gutierrez-Erlandsson S, Herrero-Vidal P, Fernandez-Alfara M, Hernandez-Garcia S, Gonzalo-Flores S, Mudarra-Rubio A, Fresno M, Cubelos B: R-RAS2 overexpression in tumors of the human central nervous system. Mol Cancer. 2013 Oct 2312(1):127., URL: https://pubmed.ncbi.nlm.nih.gov/24148564/,
• Storage Conditions: Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.