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Anti-R-RAS2 PE

CAT: 0270-1P-722-C100Size: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0270-1P-722-C100Size:0.1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
R-Ras2 / TC21 is the only member of R-Ras family of small GTPases that shows transforming activities similar to H-Ras, N-Ras, and K-Ras, and it is also structurally similar to them. R-Ras2 seems to play an important role in activating signal transduction pathways that control cell proliferation. Its mutations are associated with the growth of certain tumors, but also overexpression of the wild type form of R-Ras2 has been frequently detected in various carcinomas. Pseudogenes of R-Ras2 gene are found on chromosomes 1 and 2. Alternate splicing results in multiple transcript variants.
Certification
RUO
Reactivity
Human
Immunogen
Human TC21
Target Antigen
R-RAS2
Clone
EM-50
Applications
FC-IC (QC tested)
Concentration
0.1 mg/mL
Format
PE
Buffer
Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Other References
*Gutierrez-Erlandsson S, Herrero-Vidal P, Fernandez-Alfara M, Hernandez-Garcia S, Gonzalo-Flores S, Mudarra-Rubio A, Fresno M, Cubelos B: R-RAS2 overexpression in tumors of the human central nervous system. Mol Cancer. 2013 Oct 23;12 (1) :127., URL: https://pubmed.ncbi.nlm.nih.gov/24148564/
Storage Conditions
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Specificity
The mouse monoclonal antibody EM-50 recognizes R-Ras2 / TC21 protein (intracellular antigen) and does not react with R-Ras1, H-Ras, K-Ras, and N-Ras.
Applications Notes
Flow cytometry: Recommended dilution: 1-4 μg/ml. Intracellular staining.
Isotype
Mouse IgG1 kappa

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