Products for Research Use Only
RegisterLogin

Anti-Hu CD205 PE

CAT: 0270-1P-669-T100Size: 100 TestsDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0270-1P-669-T100Size:100 Tests
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
CD205, also known as DEC-205, is an endocytic receptor of macrophage mannose receptor family. This 205 kDa C-type lectin transmembrane protein mediates adsorptive uptake and its intracellular domain contains coated pit localization sequence and distal acidic motif, which is required for recycling beyond early endosomes through deeper MHC II+ late endosomes and lysosomes. This unique pathway of receptor-mediated uptake proves to be necessary for presentation of antigenic peptides at low doses of ligand. CD205 is responsible for uptake and processing of captured antigens for dendritic cells.
Certification
RUO
Reactivity
Human
Immunogen
Recombinant Fc-tagged human CD205
Target Antigen
CD205
Clone
HD30
Applications
FC (QC tested)
Format
PE
Buffer
Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
References & Citations
*Park CG, Rodriguez A, Ueta H, Lee H, Pack M, Matsuno K, Steinman RM: Generation of anti-human DEC205/CD205 monoclonal antibodies that recognize epitopes conserved in different mammals. 2012 Mar 30;377 (1-2) :15-22., URL: http://www.ncbi.nlm.nih.gov/pubmed/22273672
Other References
*Mahnke K, Guo M, Lee S, Sepulveda H, Swain SL, Nussenzweig M, Steinman RM: The dendritic cell receptor for endocytosis, DEC-205, can recycle and enhance antigen presentation via major histocompatibility complex class II-positive lysosomal compartments. J Cell Biol. 2000 Oct 30;151 (3) :673-84., URL: http://www.ncbi.nlm.nih.gov/pubmed/11062267, , *Guo M, Gong S, Maric S, Misulovin Z, Pack M, Mahnke K, Nussenzweig MC, Steinman RM: A monoclonal antibody to the DEC-205 endocytosis receptor on human dendritic cells. Hum Immunol. 2000 Aug;61 (8) :729-38., URL: http://www.ncbi.nlm.nih.gov/pubmed/10980384, , *Gurer C, Strowig T, Brilot F, Pack M, Trumpfheller C, Arrey F, Park CG, Steinman RM, Münz C: Targeting the nuclear antigen 1 of Epstein-Barr virus to the human endocytic receptor DEC-205 stimulates protective T-cell responses. Blood. 2008 Aug 15;112 (4) :1231-9., URL: https://www.ncbi.nlm.nih.gov/pubmed/18519810
Storage Conditions
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Specificity
The mouse monoclonal antibody HD30 recognizes an extracellular epitope of CD205, an approx. 200 kDa C-type lectin transmembrane protein of the MMR (macrophage mannose receptor) family, expressed at high levels on dendritic cells and thymic epithelial cells, and at low levels on lymphocytes, NK cells and monocytes.
Applications Notes
6
Isotype
Mouse IgG1 kappa

Related Products

CatalogName
11-669-C025Anti-Hu CD205 Purified
1A-669-T100Anti-Hu CD205 APC
11-669-C100Anti-Hu CD205 Purified
1P-640-T025Anti-Hu CD209 PE
1P-782-T100Anti-Hu CD206 PE
1P-756-T100Anti-Hu CD255 PE
1P-746-T100Anti-Hu CD200 PE
1P-756-T025Anti-Hu CD255 PE
1P-946-T100Anti-Hu CD207 PE
1P-941-T100Anti-Hu CD245 PE

Alternative Products

CatalogName
MBS1801864-01Anti-Hu CD205 APC
MBS1800687-01Anti-Hu CD205 Purified
MBS1800688-01Anti-Hu CD205 PE
STJ16100573Anti-CD205 antibody
GTR18320518Mouse Hu CD205 Purified, clone HD30 (Monoclonal) Antibody
GTR18089727Anti-CD205 [NLDC145]
MBS224615-01MOUSE ANTI BOVINE CD205
A08183-2Anti-CD205/LY75 Antibody
YLD1434-01Rabbit anti-CD205 Antibody
MBS226037-01MOUSE ANTI PIG CD205

Popular Products