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Anti-Hu CD162 PE

CAT: 0270-1P-603-T100Size: 100 TestsDry Ice: NoHazardous: No
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CAT#:0270-1P-603-T100Size:100 Tests
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CD162 (P-selectin glycoprotein ligand-1, PSGL-1) is a sialomucin constitutively expressed as a disulfide-linked homodimer of two 120 kDa subunits on the surface of circulating leukocytes. CD162 serves as a ligand for P- E- and L-selectin, with the highest affinity for P-selectin. It is thus involved in leukocyte rolling at the endothelial surfaces, prerequisite for firm leukocyte adhesion and subsequent transendothelial migration. CD162 also mediates leukocyte-platelet adhesion and interleukocyte contacts. Whereas serving as an adhession molecule on mature leukocytes, CD162 is a potent negative regulator of human hematopoietic progenitors.
Certification
RUO
Reactivity
Human
Immunogen
Human thymocytes
Target Antigen
CD162
Clone
TC2
Applications
FC (QC tested)
Format
PE
Buffer
Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
References & Citations
*Wake H, Mori S, Liu K, Morioka Y, Teshigawara K, Sakaguchi M, Kuroda K, Gao Y, Takahashi H, Ohtsuka A, Yoshino T, Morimatsu H, Nishibori M: Histidine-Rich Glycoprotein Prevents Septic Lethality through Regulation of Immunothrombosis and Inflammation. EBioMedicine. 2016 Jul;9:180-194., URL: https://www.ncbi.nlm.nih.gov/pubmed/27333033, *Nakata K, Takeda S, Tanaka A, Kwang J, Komano J: Antiviral activity of acid beta-glucosidase 1 on enterovirus 71, a causative agent of hand, foot and mouth disease. J Gen Virol. 2017 Apr;98 (4) :643-651., URL: https://www.ncbi.nlm.nih.gov/pubmed/?term=nakata+k+takeda+s+tanaka+a+kwang+j
Other References
*Moore KL: Structure and function of P-selectin glycoprotein ligand-1. Leuk Lymphoma. 1998 Mar;29 (1-2) :1-15., URL: https://www.ncbi.nlm.nih.gov/pubmed/9638971?ordina, *Lévesque JP, Zannettino AC, Pudney M, Niutta S, Haylock DN, Snapp KR, Kansas GS, Berndt MC, Simmons PJ. PSGL-1-mediated adhesion of human hematopoietic progenitors to P-selectin results in suppression of hematopoiesis. Immunity. 1999 Sep;11 (3) :369-78., URL: https://www.ncbi.nlm.nih.gov/pubmed/10514015?ordin, *Davenpeck KL, Brummet ME, Hudson SA, Mayer RJ, Bochner BS: Activation of human leukocytes reduces surface P-selectin glycoprotein ligand-1 (PSGL-1, CD162) and adhesion to P-selectin in vitro. J Immunol. 2000 Sep 1;165 (5) :2764-72., URL: https://www.ncbi.nlm.nih.gov/pubmed/10946308?ordin, *Marsik C, Mayr F, Cardona F, Schaller G, Wagner OF, Jilma B: Endotoxin down-modulates P-selectin glycoprotein ligand-1 (PSGL-1, CD162) on neutrophils in humans. J Clin Immunol. 2004 Jan;24 (1) :62-5., URL: https://www.ncbi.nlm.nih.gov/pubmed/14997035?ordin, *Leukocyte Typing VII., Mason D. et al. (Eds.), Oxford University Press (2002) ., URL:
Storage Conditions
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Specificity
+
Applications Notes
6
Isotype
Mouse IgG1

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