Anti-Hu CD41 FITC

Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Alternative Products

Cat	Name
MBS1800979-02	Anti-Hu CD41 FITC
MBS1800979-01	Anti-Hu CD41 FITC
MBS1800980-01	Anti-Hu CD41 PE
MBS1800977-02	Anti-Hu CD41 APC
MBS1800981-01	Anti-Hu CD41 PerCP
MBS1800976-02	Anti-Hu CD41 Purified
MBS1800976-01	Anti-Hu CD41 Purified
MBS1800981-02	Anti-Hu CD41 PerCP
MBS1800980-02	Anti-Hu CD41 PE
MBS1800978-02	Anti-Hu CD41 Biotin

Anti-Hu CD41 FITC

CAT:

270-1F-309-T100

Size:

100 Tests

Price:

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For price, please contact [email protected].

Anti-Hu CD41 FITC

Background: CD41 (platelet glycoprotein IIb) is composed of two subunits (120 kDa a, alpha and 23 kDa b, beta) that interact with CD61 in the presence of calcium to form a functional adhesive protein receptor. Upon blood vessel damage, this receptor binds to a variety of proteins including von Willebrand factor, fibrinogen, fibronectin and vitronectin. CD41 is mainly expressed on megakaryocyte-platelet lineage, but generally belongs to the antigens that are expressed during early stages of hematopoietic differentiation.
Specifications: The antibody MEM-06 reacts with an extracellular epitope of CD41 (GPIIb), a transmembrane glycoprotein (integrin family) composed of two chains GPIIb alpha (heavy chain 120 kDa) and GPIIb beta (light chain 23 kDa). CD41 is mainly expressed on platelets and megakaryocytes.
Certification: RUO
Host: Mouse
Species Reactivity: Human
Immunogen: Leukocytes of patient suffering from LGL-type leukaemia.
Target Antigen: CD41
Isotype: IgG1
Clone: MEM-06
Applications: Flow cytometry: The reagent is designed for analysis of human blood cells using 20 μl reagent / 100 μl of whole blood or 106 cells in a suspension. The content of a vial (2 mL) is sufficient for 100 tests.
Validated Applications: FC
Format: FITC
Buffer: Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
References & Citations: *Belizaire RM, Prakash PS, Richter JR, Robinson BR, Edwards MJ, Caldwell CC, Lentsch AB, Pritts TA: Microparticles from stored red blood cells activate neutrophils and cause lung injury after hemorrhage and resuscitation. J Am Coll Surg. 2012 Apr214(4):648-55, URL: https://pubmed.ncbi.nlm.nih.gov/22342784/,*Pagani G, Pereira JPV, Stoldt VR, Beck A, Scharf RE, Gohlke H: The human platelet antigen-1b (Pro33) variant of 945IIb9463 allosterically shifts the dynamic conformational equilibrium of this integrin toward the active state. J Biol Chem. 2018 Mar 30293(13):4830-4844., URL: https://pubmed.ncbi.nlm.nih.gov/29462793/,
Other References: *Mitjavila-Garcia MT, Cailleret M, Godin I, Nogueira MM, Cohen-Solal K, Schiavon V, Lecluse Y, Le Pesteur F, Lagrue AH, Vainchenker W: Expression of CD41 on hematopoietic progenitors derived from embryonic hematopoietic cells. Development. 2002 Apr129(8):2003-13., URL: https://www.ncbi.nlm.nih.gov/pubmed/11934866?ordin,*Ferkowicz MJ, Starr M, Xie X, Li W, Johnson SA, Shelley WC, Morrison PR, Yoder MC: CD41 expression defines the onset of primitive and definitive hematopoiesis in the murine embryo. Development. 2003 Sep130(18):4393-403., URL: https://www.ncbi.nlm.nih.gov/pubmed/12900455?ordin,*Zhang J, Varas F, Stadtfeld M, Heck S, Faust N, Graf T: CD41-YFP mice allow in vivo labeling of megakaryocytic cells and reveal a subset of platelets hyperreactive to thrombin stimulation. Exp Hematol. 2007 Mar35(3):490-499., URL: https://www.ncbi.nlm.nih.gov/pubmed/17309829?ordin,*Debili N, Robin C, Schiavon V, Letestu R, Pflumio F, Mitjavila-Garcia MT, Coulombel L, Vainchenker W: Different expression of CD41 on human lymphoid and myeloid progenitors from adults and neonates. Blood. 2001 Apr 197(7):2023-30., URL: https://www.ncbi.nlm.nih.gov/pubmed/11264167?ordin,
Storage Conditions: Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Complementary Product Range

Our range of products, including Anti-Hu CD41 FITC, falls within the same field of application and can be used across various research projects. These products are carefully selected for their high performance and reliability, supporting the diverse needs of modern laboratories. Whether for ongoing studies or future experiments, they are designed to help researchers achieve their scientific goals. Here are some related products that may be of interest for similar or future applications:

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Cat	Name
1F-309-T025	Anti-Hu CD41 FITC
1F-309-T100	Anti-Hu CD41 FITC
1P-309-T025	Anti-Hu CD41 PE
1B-309-C100	Anti-Hu CD41 Biotin
1A-309-T025	Anti-Hu CD41 APC
PC-309-T100	Anti-Hu CD41 PerCP
11-309-C025	Anti-Hu CD41 Purified
11-309-C100	Anti-Hu CD41 Purified
PC-309-T025	Anti-Hu CD41 PerCP
1P-309-T100	Anti-Hu CD41 PE