Anti-Hu CD49d FITC

Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Dry Ice Shipment: No

Alternative Products

Cat	Name
MBS1800308-01	Anti-Hu CD49d FITC
MBS1800308-02	Anti-Hu CD49d FITC
MBS1800306-02	Anti-Hu CD49d Purified
MBS1800306-01	Anti-Hu CD49d Purified
MBS1800309-01	Anti-Hu CD49d PE
MBS1800309-02	Anti-Hu CD49d PE
MBS1800310-02	Anti-Hu CD49d APC-Cyanine7
MBS1800310-01	Anti-Hu CD49d APC-Cyanine7
MBS1800307-01	Anti-Hu CD49d Purified Low Endotoxin
MBS1800307-02	Anti-Hu CD49d Purified Low Endotoxin

Anti-Hu CD49d FITC

CAT:

270-1F-171-T100

Size:

100 Tests

Price:

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For price, please contact [email protected].

Anti-Hu CD49d FITC

Background: CD49d / integrin alpha 4, unlike other alpha integrins, neither contains an I-domain, nor undergoes disulfide-linked cleavage. It associates with beta 7 chain to form alpha 4 / beta 7 integrin, and with beta 1 chain (CD29) to form VLA-4 integrin. These complexes are important for lymphocyte migration from circulation into tissue (binding VCAM-1) and homing of T cell subsets to Peyer´s patches (binding MadCAM-1), but VLA-4 is also target for invasive bacteria which contain invasin. CD49d is essential for differentiation and migration of hematopoietic stem cells by their adhesion to bone marrow stromal cells, and provides a costimulatory signal to TCR-CD3 complex by inducing phosphorylation of some focal adhesion proteins.
Specifications: The mouse monoclonal antibody 9F10 recognizes an extracellular epitope of CD49d (alpha 4 integrin), a 145-180 kDa type I transmembrane glycoprotein expressed on B and T cells, monocytes, eosinophils, basophils, NK cells, and dendritic cells, but not platelets.
Certification: RUO
Host: Mouse
Species Reactivity: Sheep, Cat, Horse, Dog, Cow, Non-human primates, Human
Target Antigen: CD49d
Isotype: Igg1 κ
Clone: 9F10
Applications: Flow cytometry: The reagent is designed for analysis of human blood cells using 4 μl reagent / 100 μl of whole blood or 106 cells in a suspension. The content of a vial (0.4 mL) is sufficient for 100 tests.
Validated Applications: FC
Format: FITC
Buffer: Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
References & Citations: *Stenner MP, Waschbisch A, Buck D, Doerck S, Einsele H, Toyka KV, Wiendl H: Effects of natalizumab treatment on Foxp3+ T regulatory cells. PLoS One. 2008 Oct 63(10):e3319. , URL: http://www.ncbi.nlm.nih.gov/pubmed/18836525,*Chigaev A, Waller A, Amit O, Halip L, Bologa CG, Sklar LA: Real-time analysis of conformation-sensitive antibody binding provides new insights into integrin conformational regulation. J Biol Chem. 2009 May 22284(21):14337-46, URL: http://www.ncbi.nlm.nih.gov/pubmed/19251697 ,*Schneider-Hohendorf T, Rossaint J, Mohan H, Böning D, Breuer J, Kuhlmann T, Gross CC, Flanagan K, Sorokin L, Vestweber D, Zarbock A, Schwab N, Wiendl H: VLA-4 blockade promotes differential routes into human CNS involving PSGL-1 rolling of T cells and MCAM-adhesion of TH17 cells. J Exp Med. 2014 Aug 25211(9):1833-46., URL: https://pubmed.ncbi.nlm.nih.gov/25135296/,*Yoon SO, Lee IY, Zhang X, Zapata MC, Choi YS: CD9 may contribute to the survival of human germinal center B cells by facilitating the interaction with follicular dendritic cells. FEBS Open Bio. 2014 Apr 134:370-6. , URL: http://www.ncbi.nlm.nih.gov/pubmed/24918051 ,*Zhang XF, Feng MF: Adherence of human monocytes and NK cells to human TNF-alpha-stimulated porcine endothelial cells. Immunol Cell Biol. 2000 Dec78(6):633-40., URL: http://www.ncbi.nlm.nih.gov/pubmed/11114974 ,*Soler D, Chapman T, Yang LL, Wyant T, Egan R, Fedyk ER: The binding specificity and selective antagonism of vedolizumab, an anti-alpha4beta7 integrin therapeutic antibody in development for inflammatory bowel diseases. J Pharmacol Exp Ther. 2009 Sep330(3):864-75., URL: https://pubmed.ncbi.nlm.nih.gov/19509315/,
Storage Conditions: Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

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Cat	Name
1F-171-T100	Anti-Hu CD49d FITC
1P-171-T025	Anti-Hu CD49d PE
11-171-C100	Anti-Hu CD49d Purified
11-171-C025	Anti-Hu CD49d Purified
1P-171-T100	Anti-Hu CD49d PE
T4-171-T100	Anti-Hu CD49d APC-Cy1537
12-171-C100	Anti-Hu CD49d Purified Low Endotoxin
1F-136-T100	Anti-Hu CD157 FITC
1F-139-T025	Anti-Hu CD89 FITC
1F-151-T100	Anti-Hu CD49b FITC