Products for Research Use Only
RegisterLogin

Anti-Hu CD264 APC

CAT: 0270-1A-519-C100Size: 0.1 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0270-1A-519-C100Size:0.1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
TRAIL-R4 (CD264, TR4, DcR2, TRUNDD), expressed mainly on CD8+ and NK cells, belongs to receptors of TRAIL, a TNF-like membrane toxic protein that induces apoptosis in many tumour cells, but not in normal cells. TRAIL-R4, however, contains partially truncated death domain, thus it is unable to induce apoptosis and serves as a negative regulator of apoptotic signaling by impairment death-inducing signaling complex (DISC) processing. TRAIL-R4 interacts with death receptor 5 (DR5) in the native DISC in a TRAIL-dependent manner and prevents its corecruitment with death receptor 4 (DR4) .
Certification
RUO
Reactivity
Human
Immunogen
TRAIL-R4 (aa 1-210) - hIgGhc fusion protein
Target Antigen
CD264
Clone
TRAIL-R4-01
Applications
FC (QC tested)
Concentration
0.1 mg/mL
Format
APC
Buffer
Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Other References
*Deligezer U, Dalay N: Expression of the TRAIL Receptors in Blood Mononuclear Cells in Leukemia. Pathol Oncol Res. 2007;13 (4) :290-4., URL: https://www.ncbi.nlm.nih.gov/pubmed/18158563?ordin, *Falschlehner C, Emmerich CH, Gerlach B, Walczak H: TRAIL signalling: decisions between life and death. Int J Biochem Cell Biol. 2007;39 (7-8) :1462-75., URL: https://www.ncbi.nlm.nih.gov/pubmed/17403612?ordin, *Mérino D, Lalaoui N, Morizot A, Schneider P, Solary E, Micheau O: Differential inhibition of TRAIL-mediated DR5-DISC formation by decoy receptors 1 and 2. Mol Cell Biol. 2006 Oct;26 (19) :7046-55., URL: https://www.ncbi.nlm.nih.gov/pubmed/16980609?ordin, *Sanlioglu AD, Dirice E, Aydin C, Erin N, Koksoy S, Sanlioglu S. Surface TRAIL decoy receptor-4 expression is correlated with TRAIL resistance in MCF7 breast cancer cells. BMC Cancer. 2005 May 25;5 (1) :54., URL: https://www.ncbi.nlm.nih.gov/pubmed/15916713?ordin, *Clancy L, Mruk K, Archer K, Woelfel M, Mongkolsapaya J, Screaton G, Lenardo MJ, Chan FK: Preligand assembly domain-mediated ligand-independent association between TRAIL receptor 4 (TR4) and TR2 regulates TRAIL-induced apoptosis. Proc Natl Acad Sci U S A. 2005 Dec 13;102 (50) :18099-104., URL: https://www.ncbi.nlm.nih.gov/pubmed/16319225?ordin
Storage Conditions
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Specificity
The antibody TRAIL-R4-01 reacts with an extracellular epitope of TRAIL-R4, a 42 kDa transmembrane protein expressed on various blood cells.
Applications Notes
Flow cytometry: Recommended dilution: 1-5 μg/ml.
Isotype
Mouse IgG1

Related Products

CatalogName
1F-519-C025Anti-Hu CD264 FITC
1F-519-C100Anti-Hu CD264 FITC
1P-519-C100Anti-Hu CD264 PE
1P-519-C025Anti-Hu CD264 PE
A6-519-C100Anti-Hu CD264 Alexa Fluor® 647
10-519-C025Anti-Hu CD264 Purified Azide Free
10-519-C100Anti-Hu CD264 Purified Azide Free
1A-461-C100Anti-Hu CD262 APC
1A-177-T100Anti-Hu CD274 APC
1A-162-T100Anti-Hu CD267 APC

Alternative Products

CatalogName
MBS1801604-01Anti-Hu CD264 PE
MBS1801603-01Anti-Hu CD264 FITC
MBS1801602-01Anti-Hu CD264 APC
MBS1802029Anti-Hu CD264 Alexa Fluor647
MBS1801601-01Anti-Hu CD264 Purified Azide Free
CQA0517-01Anti-CD264 Antibody
DL93944A-01Rabbit anti-CD264 Antibody
MBS221596-01RABBIT ANTI HUMAN CD264
CMA6134-01Recombinant Anti-CD264 Rabbit mAb
PA91043HU-01Rabbit Anti-Human CD264 Polyclonal Antibody

Popular Products