Anti-Hu CD27 APC

Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Dry Ice Shipment: No

Alternative Products

Cat	Name
MBS1800900-02	Anti-Hu CD27 PE
MBS1800899-01	Anti-Hu CD27 FITC
MBS1800900-01	Anti-Hu CD27 PE
MBS1800898-01	Anti-Hu CD27 APC
MBS1800897-02	Anti-Hu CD27 Purified
MBS1800897-01	Anti-Hu CD27 Purified
MBS1800898-02	Anti-Hu CD27 APC
MBS1800899-02	Anti-Hu CD27 FITC
MBS1802150-INQUIRE	Anti-Hu CD27 Pacific Blue
MBS1800903-02	Anti-Hu CD27 PE-Cyanine7

Anti-Hu CD27 APC

CAT:

270-1A-308-T100

Size:

100 Tests

Price:

Ask

For price, please contact [email protected].

Anti-Hu CD27 APC

Background: CD27 is a transmembrane 55 kDa protein of the nerve growth factor-receptor family, expressed as a disulfide-linked homodimer on mature thymocytes, peripheral blood T cells and a subpopulation of B cells. Activation of T cells via TCR-CD3 complex results in upregulation of CD27 expression on the plasma membrane as well as in the release of its soluble 28-32 kDa form, sCD27, detected in the plasma, urine or spinal fluid. This sCD27 is an important prognostic marker of acute and chronic B cell malignancies. RgpA, a cystein proteinase, although activating T cells through the protease-activated receptors (PARs), degradates CD27 and counteracts T cell activation mediated by CD27 and its ligand CD70.
Specifications: The antibody LT27 reacts with an extracellular epitope of CD27 (T14), a 50-55 kDa type I transmembrane glycoprotein (member of the TNF-receptor superfamily) expressed on medullary thymocytes, peripheral T lymphocytes, some B lymphocytes and NK cells.
Certification: RUO
Host: Mouse
Species Reactivity: Human
Immunogen: Human peripheral blood lymphocytes
Target Antigen: CD27
Isotype: IgG2a
Clone: LT27
Applications: Flow cytometry: The reagent is designed for analysis of human blood cells using 10 μl reagent / 100 μl of whole blood or 106 cells in a suspension. The content of a vial (1 mL) is sufficient for 100 tests.
Validated Applications: FC
Format: APC
Buffer: Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
References & Citations: *Kanderova V, Kuzilkova D, Stuchly J, Vaskova M, Brdicka T, Fiser K, Hrusak O, Lund-Johansen F, Kalina T: High-resolution Antibody Array Analysis of Childhood Acute Leukemia Cells. Mol Cell Proteomics. 2016 Apr15(4):1246-61., URL: http://www.ncbi.nlm.nih.gov/pubmed/26785729,
Other References: *Yun LW, Decarlo AA, Hunter N: Blockade of protease-activated receptors on T cells correlates with altered proteolysis of CD27 by gingipains of Porphyromonas gingivalis. Clin Exp Immunol. 2007 Nov150(2):217-29., URL: https://www.ncbi.nlm.nih.gov/pubmed/17937677?ordin,*Kara IO, Sahin B, Gunesacar R: Expression of soluble CD27 and interleukins-8 and -10 in B-cell chronic lymphocytic leukemia: correlation with disease stage and prognosis. Adv Ther. 2007 Jan-Feb24(1):29-40., URL: https://www.ncbi.nlm.nih.gov/pubmed/17526459?ordin,*Molica S, Vitelli G, Levato D, Crispino G, Dell'Olio M, Dattilo A, Matera R, Gandolfo GM, Musto P. CD27 in B-cell chronic lymphocytic leukemia. Cellular expression, serum release and correlation with other soluble molecules belonging to nerve growth factor receptors (NGFr) superfamily. Haematologica. 1998 May83(5):398-402., URL: https://www.ncbi.nlm.nih.gov/pubmed/9658722?ordina,*van Oers MH, Pals ST, Evers LM, van der Schoot CE, Koopman G, Bonfrer JM, Hintzen RQ, von dem Borne AE, van Lier RA: Expression and release of CD27 in human B-cell malignancies. Blood. 1993 Dec 182(11):3430-6., URL: https://www.ncbi.nlm.nih.gov/pubmed/8241510?ordina,
Storage Conditions: Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Complementary Product Range

Our range of products, including Anti-Hu CD27 APC, falls within the same field of application and can be used across various research projects. These products are carefully selected for their high performance and reliability, supporting the diverse needs of modern laboratories. Whether for ongoing studies or future experiments, they are designed to help researchers achieve their scientific goals. Here are some related products that may be of interest for similar or future applications:

Each item in our collection, is tested for precision and quality, ensuring dependable solutions for your research. As we continue to incorporate the latest advancements, Gentaur ensures that our product range remains relevant and versatile, providing you with the tools needed for both current and future projects.

Find us on

Cat	Name
1P-308-T100	Anti-Hu CD27 PE
1A-308-T100	Anti-Hu CD27 APC
11-308-C025	Anti-Hu CD27 Purified
11-308-C100	Anti-Hu CD27 Purified
1A-308-T025	Anti-Hu CD27 APC
1F-308-T025	Anti-Hu CD27 FITC
1F-308-T100	Anti-Hu CD27 FITC
1P-308-T025	Anti-Hu CD27 PE
T4-308-T100	Anti-Hu CD27 APC-Cy1537
T9-308-T100	Anti-Hu CD27 PerCP-Cy1535.5