Anti-Insulin Purified Low Endotoxin

Anti-Insulin Purified Low Endotoxin

• Background: Insulin and glucagon are pancreatic endocrine hormones secreted by islet cells within the pancreas. The stimulus for insulin secretion is a HIGH blood glucose. Deficiency of insulin results in diabetes mellitus, one of the leading causes of morbidity and mortality in the general population.
• Specifications: The antibody IN-05 reacts with insulin, one of the major regulatory endocrine hormones of intermediate metabolism, normally secreted by the beta cells (a type of islet cells) of the pancreas it is also present in tumors of B cell origin such as insulinoma.
• CAS Number: 9007-83-4
• Certification: RUO
• Host: Mouse
• Species Reactivity: Pig, Cow, Human
• Immunogen: Porcine insulin.
• Target Antigen: Insulin
• Isotype: IgG1
• Clone: IN-05
• Applications: Functional application: The antibody IN-05 blocks binding of insulin to the receptor.
• Validated Applications: ELISA, RIA, IHC-P, ICC, Functional assays
• Concentration: 1 mg/mL
• Format: Purified Low Endotoxin
• Buffer: Phosphate buffered saline (PBS), pH 7.4
• References & Citations: *Horejsi V, Hilgert I, Kristofova H, Satayalai O: Murine hybridoma monoclonal antibodies against insulin: cross-reactivity with insulins of three species and blocking of insulin binding to its receptor. Immunol Lett. 19848(5):279-83., URL: https://pubmed.ncbi.nlm.nih.gov/6083978/,
• Storage Conditions: Store at 2-8°C. Do not freeze.