Anti-Hu CD279 Purified Low Endotoxin

Anti-Hu CD279 Purified Low Endotoxin

• Background: CD279 / PD-1 (programmed cell death 1), a transmembrane protein of CD28/CTLA-4 family. It is expressed inducibly mainly on activated T, B, and myeloid cells and plays a role in maintaining peripheral self-tolerance. Binding to its ligands CD273 and CD274 is associated with inhibition of T cell proliferation and induction of their anergy. It is also expressed during thymic development. Some variants of CD279 are associated with susceptibility to systemic lupus erythematosus, type 1 diabetes, and rheumatoid arthritis.
• Specifications: The mouse monoclonal antibody EH12.2H7 recognizes an extracellular epitope of CD279 / PD-1 (programmed cell death 1), a 55 kDa type I transmembrane protein expressed above all during T cell development, on activated T cells, activated B cells, and activated monocytes.
• CAS Number: 9007-83-4
• Certification: RUO
• Host: Mouse
• Species Reactivity: Non-human primates, Human
• Immunogen: recombinant human CD279
• Target Antigen: CD279
• Isotype: Igg1 κ
• Clone: EH12.2H7
• Applications: Functional application: Blocking. Flow cytometry: Recommended dilution: 1-4 µg/mL
• Validated Applications: FC, IHC-F, Functional assays
• Concentration: 1 mg/mL
• Format: Purified Low Endotoxin
• Buffer: Phosphate buffered saline (PBS), pH 7.4
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• Storage Conditions: Store at 2-8°C. Do not freeze.