Anti-Hu CD144 Purified

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MBS1800238-01	Anti-Hu CD144 Purified
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MBS1800240-02	Anti-Hu CD144 PE-Cyanine7

CAT:

270-11-770-C100

Size:

0.1 mg

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Anti-Hu CD144 Purified

Background: CD144 / VE-cadherin (cadherin 5) is the major cadherin that is present at endothelial junctions. It is also strictly endothelial specific. Under vascular permeability increasing conditions (and also in capillaries and veins) CD144 is being phosphorylated, which promotes its rapid and reversible internalization. On the contrary, binding of p120 catenin (delta1 catenin) maintains CD144 localization at the plasma membrane, which stabilizes the junction and reduces vascular permeability.
Specifications: The mouse monoclonal antibody 55-7H1 recognizes a calcium-independent extracellular epitope on CD144 (VE-cadherin, cadherin 5), an adhesion molecule expressed on endothelial cells.
Certification: RUO
Host: Mouse
Species Reactivity: Human
Immunogen: Human endothelial cells
Target Antigen: CD144
Isotype: Igg1 κ
Clone: 55-7H1
Applications: Flow cytometry: Recommended dilution: 1-4 μg/mL.
Validated Applications: FC, IP, WB, IHC-F, ICC
Concentration: 1 mg/mL
Format: Purified
Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
References & Citations: *Tisato V, Zauli G, Voltan R, Gianesini S, di Iasio MG, Volpi I, Fiorentini G, Zamboni P, Secchiero P: Endothelial cells obtained from patients affected by chronic venous disease exhibit a pro-inflammatory phenotype. PLoS One. 20127(6):e39543., URL: http://www.ncbi.nlm.nih.gov/pubmed/22737245 ,*Agrawal V, Kelly J, Tottey S, Daly KA, Johnson SA, Siu BF, Reing J, Badylak SF: An isolated cryptic peptide influences osteogenesis and bone remodeling in an adult mammalian model of digit amputation. Tissue Eng Part A. 2011 Dec17(23-24):3033-44., URL: http://www.ncbi.nlm.nih.gov/pubmed/?term=agrawal+v+kelly+j+tottey+s ,*De Ugarte DA, Alfonso Z, Zuk PA, Elbarbary A, Zhu M, Ashjian P, Benhaim P, Hedrick MH, Fraser JK: Differential expression of stem cell mobilization-associated molecules on multi-lineage cells from adipose tissue and bone marrow. Immunol Lett. 2003 Oct 3189(2-3):267-70., URL: http://www.ncbi.nlm.nih.gov/pubmed/14556988 ,*Limaye V, Li X, Hahn C, Xia P, Berndt MC, Vadas MA, Gamble JR: Sphingosine kinase-1 enhances endothelial cell survival through a PECAM-1-dependent activation of PI-3K/Akt and regulation of Bcl-2 family members. Blood. 2005 Apr 15105(8):3169-77, URL: http://www.ncbi.nlm.nih.gov/pubmed/15632208 ,*Hamilton RD, Foss AJ, Leach L: Establishment of a human in vitro model of the outer blood-retinal barrier. J Anat. 2007 Dec211(6):707-16, URL: http://www.ncbi.nlm.nih.gov/pubmed/17922819,
Other References: *Dejana E, Orsenigo F: Endothelial adherens junctions at a glance. J Cell Sci. 2013 Jun 15126(Pt 12):2545-9., URL: http://www.ncbi.nlm.nih.gov/pubmed/23781019,
Storage Conditions: Store at 2-8°C. Do not freeze.

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11-770-C025	Anti-Hu CD144 Purified
11-770-C100	Anti-Hu CD144 Purified
1P-770-T100	Anti-Hu CD144 PE
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A4-770-T100	Anti-Hu CD144 Alexa Fluor® 488
A6-770-T100	Anti-Hu CD144 Alexa Fluor® 647
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