Anti-Hu CD26 Purified

Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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MBS1800392-02	Anti-Hu CD26 Purified
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MBS1800394-01	Anti-Hu CD26 FITC
MBS1800393-02	Anti-Hu CD26 APC
MBS1800394-02	Anti-Hu CD26 FITC
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MBS1800663-02	Anti-Ms CD26 Purified

CAT:

270-11-608-C100

Size:

0.1 mg

Price:

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Anti-Hu CD26 Purified

Background: CD26, also known as dipeptidyl peptidase IV (DPP-IV), is a homodimeric cell surface serine peptidase that degradates IFN-gamma-induced cytokines, acts as a T cell costimulatory molecule, and participates in multiple immunopathological roles in leukocyte homing and inflammation. Alterations in its peptidase activity are characteristic of malignant transformation. The enzymatic activity increases dramatically with tumour grade and severity. CD26 is expressed in various blood cell types, but also e.g. in cells that are histogenetically related to activated fibroblasts. Alterations in CD26 density have been reported on circulating monocytes and CD4+ T cells during rheumatoid arthritis and systemic lupus erythematosus.
Specifications: The mouse monoclonal antibody BA5b recognizes an extracellular epitope of CD26, a 110 kDa type II transmembrane glycoprotein, which is a peptidase expressed on mature thymocytes, T cells (especially activated), B cells, NK cells and macrophages.
Certification: RUO
Host: Mouse
Species Reactivity: Human
Immunogen: A human T cell clone
Target Antigen: CD26
Isotype: IgG2a
Clone: BA5b
Applications: Flow cytometry: Recommended dilution: 1-2 μg/mL positive control: human peripheral blood leukocytes.
Validated Applications: FC
Concentration: 1 mg/mL
Format: Purified
Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Other References: *Wong PT, Wong CK, Tam LS, Li EK, Chen DP, Lam CW: Decreased expression of T lymphocyte co-stimulatory molecule CD26 on invariant natural killer T cells in systemic lupus erythematosus. Immunol Invest. 200938(5):350-64., URL: https://www.ncbi.nlm.nih.gov/pubmed/19811413?ordin,*Dohi O, Ohtani H, Hatori M, Sato E, Hosaka M, Nagura H, Itoi E, Kokubun S: Histogenesis-specific expression of fibroblast activation protein and dipeptidylpeptidase-IV in human bone and soft tissue tumours. Histopathology. 2009 Oct55(4):432-40., URL: https://www.ncbi.nlm.nih.gov/pubmed/19817894?ordin,*Kotacková L, Baláziová E, Sedo A: Expression pattern of dipeptidyl peptidase IV activity and/or structure homologues in cancer. Folia Biol (Praha). 200955(3):77-84., URL: https://www.ncbi.nlm.nih.gov/pubmed/19545486?ordin,*Stremenova J, Krepela E, Mares V, Trim J, Dbaly V, Marek J, Vanickova Z, Lisa V, Yea C, Sedo A: Expression and enzymatic activity of dipeptidyl peptidase-IV in human astrocytic tumours are associated with tumour grade. Int J Oncol. 2007 Oct31(4):785-92., URL: https://www.ncbi.nlm.nih.gov/pubmed/17786309?ordin,*Ellingsen T, Hornung N, Møller BK, Hjelm-Poulsen J, Stengaard-Pedersen K: In active chronic rheumatoid arthritis, dipeptidyl peptidase IV density is increased on monocytes and CD4(+) T lymphocytes. Scand J Immunol. 2007 Oct66(4):451-7., URL: https://www.ncbi.nlm.nih.gov/pubmed/17850590?ordin,
Storage Conditions: Store at 2-8°C. Do not freeze.

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Cat	Name
11-608-C100	Anti-Hu CD26 Purified
11-608-C025	Anti-Hu CD26 Purified
1P-608-T025	Anti-Hu CD26 PE
1P-608-T100	Anti-Hu CD26 PE
1F-608-T025	Anti-Hu CD26 FITC
1F-608-T100	Anti-Hu CD26 FITC
1A-608-T025	Anti-Hu CD26 APC
1A-608-T100	Anti-Hu CD26 APC
PB-608-T025	Anti-Hu CD26 Pacific Blue153
PB-608-T100	Anti-Hu CD26 Pacific Blue153