Anti-Hu CD42b Purified

Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Dry Ice Shipment: No

Alternative Products

Cat	Name
MBS1800341-02	Anti-Hu CD42b Purified
MBS1800714-02	Anti-Hu CD42b Purified
MBS1800341-01	Anti-Hu CD42b Purified
MBS1800714-01	Anti-Hu CD42b Purified
MBS1800342-01	Anti-Hu CD42b Purified Low Endotoxin
MBS1800342-02	Anti-Hu CD42b Purified Low Endotoxin
M02073	Anti-Hu CD42b Purified GP1BA Monoclonal Antibody
M02073-1	Anti-Hu CD42b Purified GP1BA Monoclonal Antibody
MBS1800345-01	Anti-Hu CD42b PE
MBS1800343-01	Anti-Hu CD42b APC

CAT:

270-11-150-C100

Size:

0.1 mg

Price:

Ask

For price, please contact [email protected].

Anti-Hu CD42b Purified

Background: CD42b (GPIb alpha) composes together with GPIb beta, GPIX and GPV the GPIb-IX-V receptor complex critical in the process of platelet-rich thrombus formation by tethering the platelet to a thrombogenic surface. CD42b binds to von Willebrand factor (VWF) exposed at a site of vascular injury, as well as to thrombin, coagulation factors XI and XII, high molecular weight kininogen, TSP-1, integrin Mac-1 and P-selectin. The extracellular domain of CD42b by its interactions also contributes to metastasis.
Specifications: The mouse monoclonal antibody AK2 recognizes an extracellular epitope of CD42b (GPIb alpha), a 135-145 kDa membrane glycoprotein expressed on platelets and megakaryocytes. CD42b and CD42c (GPIb beta) are composed in a disulfide linked heterodimer (CD42b/c 160 kDa) CD42b/c forms a noncovalent complex with CD42a and CD42d.
Certification: RUO
Host: Mouse
Species Reactivity: Human
Immunogen: Human platelets
Target Antigen: CD42b
Isotype: IgG1
Clone: AK2
Applications: Flow cytometry: Recommended dilution: 1-4 μg/mL.
Validated Applications: FC, IP, WB, ICC, ELISA
Concentration: 1 mg/mL
Format: Purified
Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
References & Citations: *Vettore S, Scandellari R, Moro S, Lombardi AM, Scapin M, Randi ML, Fabris F: Novel point mutation in a leucine-rich repeat of the GPIbalpha chain of the platelet von Willebrand factor receptor, GPIb/IX/V, resulting in an inherited dominant form of Bernard-Soulier syndrome affecting two unrelated families: the N41H variant. Haematologica. 2008 Nov93(11):1743-7. doi: 10.3324/haematol.12830., URL: https://pubmed.ncbi.nlm.nih.gov/18815197/,*Welsh JD, Colace TV, Muthard RW, Stalker TJ, Brass LF, Diamond SL: Platelet-targeting sensor reveals thrombin gradients within blood clots forming in microfluidic assays and in mouse. J Thromb Haemost. 2012 Nov10(11):2344-53., URL: http://www.ncbi.nlm.nih.gov/pubmed/22978514 ,
Other References: *Bergmeier W, Piffath CL, Goerge T, Cifuni SM, Ruggeri ZM, Ware J, Wagner DD: The role of platelet adhesion receptor GPIbalpha far exceeds that of its main ligand, von Willebrand factor, in arterial thrombosis. Proc Natl Acad Sci U S A. 2006 Nov 7103(45):16900-5., URL: https://www.ncbi.nlm.nih.gov/pubmed/17075060?ordin,*Vanhoorelbeke K, Ulrichts H, Van de Walle G, Fontayne A, Deckmyn H: Inhibition of platelet glycoprotein Ib and its antithrombotic potential. Curr Pharm Des. 200713(26):2684-97., URL: https://www.ncbi.nlm.nih.gov/pubmed/17897012?ordin,*Jain S, Zuka M, Liu J, Russell S, Dent J, Guerrero JA, Forsyth J, Maruszak B, Gartner TK, Felding-Habermann B, Ware J. Platelet glycoprotein Ib alpha supports experimental lung metastasis. Proc Natl Acad Sci U S A. 2007 May 22104(21):9024-8., URL: https://www.ncbi.nlm.nih.gov/pubmed/17494758?ordin,
Storage Conditions: Store at 2-8°C. Do not freeze.

Complementary Product Range

Our range of products, including Anti-Hu CD42b Purified, falls within the same field of application and can be used across various research projects. These products are carefully selected for their high performance and reliability, supporting the diverse needs of modern laboratories. Whether for ongoing studies or future experiments, they are designed to help researchers achieve their scientific goals. Here are some related products that may be of interest for similar or future applications:

Each item in our collection, is tested for precision and quality, ensuring dependable solutions for your research. As we continue to incorporate the latest advancements, Gentaur ensures that our product range remains relevant and versatile, providing you with the tools needed for both current and future projects.

Find us on

Cat	Name
11-150-C100	Anti-Hu CD42b Purified
11-367-C100	Anti-Hu CD42b Purified
11-150-C025	Anti-Hu CD42b Purified
11-367-C025	Anti-Hu CD42b Purified
12-150-C100	Anti-Hu CD42b Purified Low Endotoxin
1A-150-T100	Anti-Hu CD42b APC
1F-150-T025	Anti-Hu CD42b FITC
1F-150-T100	Anti-Hu CD42b FITC
1P-150-T100	Anti-Hu CD42b PE
1P-150-T025	Anti-Hu CD42b PE