Anti-Hu CD172b Purified

Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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MBS1800387-02	Anti-Hu CD172b Purified
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CAT:

270-11-134-C100

Size:

0.1 mg

Price:

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Anti-Hu CD172b Purified

Background: CD172b, the signal-regulatory protein beta (SIRP beta) is a disulfide-linked homodimer expressed on myeloid cells including monocytes and dendritic cells. Similarly to CD172a, it serves as a negative regulator of tyrosine kinase-coupled signaling processes. Unlike CD172a, the CD172b protein does not possess the cytoplasmic domain, but instead its transmembrane domain can interact with another transmembrane protein DAP-12, which contains ITAM sequences in its intracellular domain and links CD172b to the downstream signaling molecules. The result is e.g. regulation of neutrophil transepithelial migration.
Specifications: The mouse monoclonal antibody B4B6 recognizes an extracellular epitope of CD172b, an approximately 50 kDa transmembrane glycoprotein expressed on myeloid cells.
Certification: RUO
Host: Mouse
Species Reactivity: Human
Immunogen: NIH-3T3 cells transfected with human CD172b
Target Antigen: CD172b
Isotype: IgG1
Clone: B4B6
Applications: Flow cytometry: Recommended dilution: 1-4 μg/mL.
Validated Applications: FC
Concentration: 1 mg/mL
Format: Purified
Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
References & Citations: *Baba N, Van VQ, Wakahara K, Rubio M, Fortin G, Panzini B, Soucy G, Wassef R, Richard C, Tamaz R, Lahaie R, Bernard EJ, Caussignac Y, Leduc R, Lougnarath R, Bergeron C, Racicot MA, Bergeron F, Panzini MA, Demetter P, Franchimont D, Schäkel K, Weckbecker G, Kolbinger F, Heusser C, Huber T, Welzenbach K, Sarfati M: CD47 fusion protein targets CD172a+ cells in Crohn's disease and dampens the production of IL-1946 and TNF. J Exp Med. 2013 Jun 3210(6):1251-63., URL: http://www.ncbi.nlm.nih.gov/pubmed/23669395,
Storage Conditions: Store at 2-8°C. Do not freeze.

Complementary Product Range

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