Orexin A (human, rat, mouse)

Orexin A (human, rat, mouse)

• CAS Number: 205640-90-0
• UNSPSC Description: Orexin A (human, rat, mouse) (Hypocretin-1 (human, rat, mouse)), a 33 amino acid excitatory neuropeptide, orchestrates diverse central and peripheral processes. Orexin A (human, rat, mouse) binds and activates two types of G protein-coupled receptors, the orexin-1 receptor (OX1R) and the orexin-2 receptor (OX2R). Orexin A (human, rat, mouse) has a role in the regulation of feeding behavior. Orexin A (human, rat, mouse) is an effective anti-nociceptive and anti-hyperalgesic agent in mice and rats[1][2].
• Target Antigen: Orexin Receptor (OX Receptor)
• Type: Peptides
• Related Pathways: GPCR/G Protein;Neuronal Signaling
• Applications: Neuroscience-Neuromodulation
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/Rat_orexin_A.html
• Purity: 99.67
• Solubility: DMSO : 100 mg/mL (ultrasonic)|H2O : ≥ 50 mg/mL
• Smiles: O=C([C@H]1N(CCC1)C([C@@H]2CCC(N2)=O)=O)N[C@@H](CC(C)C)C(N3[C@@H](CCC3)C(N[C@@H](CC(O)=O)C(N[C@@H]4C(N[C@]5([H])C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@](C(N[C@@](C(N[C@H](C(N[C@@H](CSSC5)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(C)C)C(N[C@H](C(N[C@@H](CCC(O)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@H](C(NCC(N[C@@H](C)C(NCC(N[C@@H](CC(N)=O)C(N[C@H](C(N[C@@H](C)C(N[C@@H](C)C(NCC(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC(C)C)C(N[C@@H]([C@H](O)C)C(N[C@H](C(N)=O)CC(C)C)=O)=O)=O)=O)=O)=O)=O)CC6=CN=CN6)=O)=O)=O)=O)=O)CC7=CN=CN7)=O)=O)=O)=O)CC8=CC=C(C=C8)O)=O)=O)=O)=O)CO)=O)([H])CSSC4)=O)([H])[C@H](O)C)=O)CCCCN)=O)CCC(N)=O)=O)CCCNC(N)=N)=O)=O)=O)=O)=O
• Molecular Weight: 3561.10
• References & Citations: [1]Sakurai T, et al. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell. 1998 Feb 20;92(4):573-85.|[2]Bingham S, et al. Orexin-A, an hypothalamic peptide with analgesic properties. Pain. 2001 May;92(1-2):81-90.|[3]Kaminski T, et al. Expression of orexin receptors in the pituitary. Vitam Horm. 2012;89:61-73.
• Shipping Conditions: Blue Ice
• Storage Conditions: -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
• Clinical Information: No Development Reported