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IL1RA rabbit pAb

CAT: 0855-ES20257-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES20257-01Size:50 µL
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Background
Disease:Genetic variation in IL1RN is associated with susceptibility to diabetic nephropathy [MIM:612628]; also called susceptibility to microvascular complications of diabetes type 4 (MVCD4) . Diabetic nephropathy is a kidney disease and resultant kidney function impairment due to the long standing effects of diabetes on the microvasculature (glomerulus) of the kidney. Features include increased urine protein and declining kidney function., function:Inhibits the activity of IL-1 by binding to its receptor. Has no IL-1 like activity., online information:Interleukin-1 entry, online information:The Singapore human mutation and polymorphism database, pharmaceutical:Available under the name Kineret (Amgen) . Used for the reduction in signs and symptoms and slowing the progression of structural damage in moderately to severely active rheumatoid arthritis., similarity:Belongs to the IL-1 family., tissue specificity:The intracellular form of IL1RN is predominantly expressed in epithelial cells.
Description
Disease: Genetic variation in IL1RN is associated with susceptibility to diabetic nephropathy [MIM: 612628]; also called susceptibility to microvascular complications of diabetes type 4 (MVCD4). Diabetic nephropathy is a kidney disease and resultant kidney function impairment due to the long standing effects of diabetes on the microvasculature (glomerulus) of the kidney. Features include increased urine protein and declining kidney function. function: Inhibits the activity of IL-1 by binding to its receptor. Has no IL-1 like activity. online information: Interleukin-1 entry, online information: The Singapore human mutation and polymorphism database, pharmaceutical: Available under the name Kineret (Amgen). Used for the reduction in signs and symptoms and slowing the progression of structural damage in moderately to severely active rheumatoid arthritis. similarity: Belongs to the IL-1 family. tissue specificity: The intracellular form of IL1RN is predominantly expressed in epithelial cells.
UniProt
P18510
Swiss Prot
P18510
Reactivity
Human; Rat; Mouse
Immunogen
Synthesized peptide derived from human IL1RA
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
WB 1:1000-2000 ELISA 1:5000-20000
Storage Conditions
-20°C/1 year
Fragment
IgG
Subcellular Location
[Isoform 1]: Secreted.; [Isoform 2]: Cytoplasm.; [Isoform 3]: Cytoplasm.; [Isoform 4]: Cytoplasm.
Other Product Names
Interleukin-1 receptor antagonist protein (IL-1RN; IL-1ra; IRAP; ICIL-1RA; IL1 inhibitor; Anakinra)
Gene ID (Human)
3557

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