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Recombinant Exendin-4

CAT: 0355-AP60499Size: InquireDry Ice: NoHazardous: No
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CAT#:0355-AP60499Size:Inquire
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Background
Exendin-4 is a novel 39-amino acid peptide isolated from the venom of the Gila monster Heloderma suspectum. It shares 53% sequence homology with GLP-17-36amide and interacts with the same membrane receptor. Exendin-4 enhances glucose-dependent insulin secretion, suppresses inappropriately elevated glucagon secretion, and slows gastric emptying in vivo. It also promotes szlig; -cell proliferation and neogenesis in vitro and in animal models. Recombinant Exendin-4 is E. coli expression of a synthetic DNA squence encoding the 39 amino acid of Exendin-4.
Product Name Alternative
Exenatide
UniProt
P26349
Target
HGEGTFTSDL SKQMEEEAVR LFIEWLKNGG PSSGAPPPS
Purification
> 96 % by SDS-PAGE and HPLC analyses.
Endotoxin
Less than 10 EU/mg of rExendin-4 as determined by LAL method.
Bioactivity
1. Regulates Glucose levels rapidly;2. Reduces Insulin resistance;3. Reduces Glucagon;4. Reduces HbA1c;5. Stimulates beta cell growth which stimulates insulin production.
Storage Conditions
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.- 12 months from date of receipt, -20 to -70 °C as supplied.- 1 month, 2 to 8 °C under sterile conditions after reconstitution.- 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Calculated Molecular Weight
Approximately 4.2 kDa, a single non-glycosylated polypeptide chain containing 39 amino acids.
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS, pH 7.4.
Host or Source
Escherichia coli

UniProtKB · P26349

Exendin-4

EXE4_HELSU · Heloderma suspectum

View on UniProt ↗
Primary accession
P26349
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
—
Protein existence
1: Evidence at protein level
Organism
Heloderma suspectum (Gila monster)
Taxonomy ID
8554
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
—
Protein keywords

Technical term

3D-structureDirect protein sequencingPharmaceutical

PTM

AmidationCleavage on pair of basic residues

Molecular function

G protein-coupled receptor impairing toxinHypotensive agentToxin

Cellular component

Secreted

Domain

Signal

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