Pyraclostrobin

• Description :

  Pyraclostrobin is a highly effective and broad-spectrum strobilurin fungicide. Pyraclostrobin can induce oxidative DNA damage, mitochondrial dysfunction and autophagy through the activation of AMPK/mTOR signaling. Pyraclostrobin can be used to control crop diseases[1][2][3].

• UNSPSC :

  12352005

• Hazard Statement :

  H315, H331, H410

• Target :

  AMPK; Autophagy; Bacterial; Bcl-2 Family; Beclin1; Fungal; mTOR

• Type :

  Reference compound

• Related Pathways :

  Anti-infection; Apoptosis; Autophagy; Epigenetics; PI3K/Akt/mTOR

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Infection; Metabolic Disease

• Assay Protocol :

  https://www.medchemexpress.com/pyraclostrobin.html

• Purity :

  99.91

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  COC(N(C1=C(C=CC=C1)COC2=NN(C3=CC=C(Cl)C=C3)C=C2)OC)=O

• Molecular Formula :

  C19H18ClN3O4

• Molecular Weight :

  387.82

• Precautions :

  H315, H331, H410

• References & Citations :

  [1]Wu M, et al. Characterization of hepatotoxic effects induced by pyraclostrobin in human HepG2 cells and zebrafish larvae [J]. Chemosphere, 2023, 340: 139732.|[2]Zhang C, et al. Acute and subchronic toxicity of pyraclostrobin in zebrafish (Danio rerio) [J]. Chemosphere, 2017, 188: 510-516.|[3]Li H, et al. Mitochondrial dysfunction-based cardiotoxicity and neurotoxicity induced by pyraclostrobin in zebrafish larvae [J]. Environmental Pollution, 2019, 251: 203-211.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, protect from light)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  Bax; Bcl-2

• CAS Number :

  [175013-18-0]