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Demethylsuberosin

CAT: 0804-HY-N2488-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N2488-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Demethylsuberosin (7-Demethylsuberosin) is a coumarin compound found in Angelica gigas Nakai. Demethylsuberosin exerts antihypertensive effects by inhibiting the L-type CaV1.2 channel. Demethylsuberosin has antioxidant and anti-inflammatory activities. Demethylsuberosin also exhibits neuroprotective activities against glutamate-induced toxicity in primary cultured rat cortical cells[1][2][3].
CAS Number
21422-04-8
Product Name Alternative
7-Demethylsuberosin
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Calcium Channel; NO Synthase
Type
Natural Products
Related Pathways
Immunology/Inflammation; Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/demethylsuberosin.html
Purity
99.71
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C1C=CC2=CC(C/C=C(C)\C)=C(O)C=C2O1
Molecular Formula
C14H14O3
Molecular Weight
230.26
Precautions
H315, H319, H335
References & Citations
[1]Yongfen Ma, et al. Anti-inflammatory Activities of Coumarins Isolated from Angelica gigas Nakai on LPS-stimulated RAW 264.7 Cells. J Food Sci Nutr Vol 14, p 179～187 (2009) .|[2]Yang X, et al. Angelica decursiva exerts antihypertensive activity by inhibiting L-type calcium channel. J Ethnopharmacol. 2023 Sep 15;313:116527.|[3]Kang SY, et al. Neuroprotective coumarins from the root of Angelica gigas: structure-activity relationships. Arch Pharm Res. 2007 Nov;30 (11) :1368-73.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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