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NSC260594

CAT: 0804-HY-112591-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-112591-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
NSC260594 induces Apoptosis. NSC260594 binds the shallow groove of the Mcl-1 protein, and inhibits Mcl-1 expression through down-regulation of Wnt signaling proteins. NSC260594 can also recognize G9-G10-A11-G12 RNA tetraloop of HIV and prevent the binding of the Gag protein within the 5’-UTR. NSC260594 inhibits tumor growth, and can be used for research of Triple-negative breast cancers (TNBCs) [1].
CAS Number
906718-66-9
Product Name Alternative
XMH95
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Apoptosis; Bcl-2 Family; HIV; Wnt
Type
Reference compound
Related Pathways
Anti-infection; Apoptosis; Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nsc260594.html
Purity
96.00
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C(NC1=CC=C(/N=C2C=CN(C)C=C\2)C=C1)C3=CC=C(/N=C4C=CN(C)C5=C\4C=C([N+]([O-])=O)C=C5)C=C3
Molecular Formula
C29H24N6O3
Molecular Weight
504.54
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362-P403+P233-P405-P501
References & Citations
[1]Dong S, et al. Targeting Mcl-1 by a small molecule NSC260594 for triple-negative breast cancer therapy. Sci Rep. 2023 Jul 22;13 (1) :11843.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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CatalogName
BA1941-5NSC260594

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