Fluxapyroxad

• Description:

  Fluxapyroxad is a synthetic broad-spectrum fungicide for the control of fungal diseases. Fluxapyroxad inhibits succinate dehydrogenase in complex II of the mitochondrial respiratory chain, resulting in inhibition of spore germination, germ tubes and mycelia growth within the fungus target species[1].

• UNSPSC:

  12352005

• Hazard Statement:

  H351, H362, H410

• Target:

  Antibiotic; Cytochrome P450; Fungal; Succinate Dehydrogenase

• Type:

  Reference compound

• Related Pathways:

  Anti-infection; Metabolic Enzyme/Protease

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection; Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/fluxapyroxad.html

• Concentration:

  10mM

• Purity:

  99.96

• Solubility:

  DMSO : ≥ 100 mg/mL

• Smiles:

  O=C(C1=CN(C)N=C1C(F)F)NC2=CC=CC=C2C3=CC(F)=C(F)C(F)=C3

• Molecular Formula:

  C18H12F5N3O

• Molecular Weight:

  381.30

• Precautions:

  H351, H362, H410

• References & Citations:

  [1]Chen X, et al. Effective Monitoring of Fluxapyroxad and Its Three Biologically Active Metabolites in Vegetables, Fruits, and Cereals by Optimized QuEChERS Treatment Based on UPLC-MS/MS. J Agric Food Chem. 2016 Nov 23;64 (46) :8935-8943. |[2]Cao Y, et al., Fluxapyroxad induces chronic colonic inflammation via inhibiting intestinal aryl hydrocarbon receptors in mice. Sci Total Environ. 2025 Apr 10;973:179134.|[3]Chen X, et al., Fluxapyroxad disrupt erythropoiesis in zebrafish (Danio rerio) embryos. Ecotoxicol Environ Saf. 2022 Dec 1;247:114259.|[4]Bénit P, et al., Evolutionarily conserved susceptibility of the mitochondrial respiratory chain to SDHI pesticides and its consequence on the impact of SDHIs on human cultured cells. PLoS One. 2019 Nov 7;14 (11) :e0224132.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [907204-31-3]