L 684248

CAT: 0804-HY-117591Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-117591Size:1 Each

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

L-684248 is an inhibitor of human leukocyte elastase (HLE) . L-684248 exerts its inhibitory effect on HLE by forming a covalent bond with the active site of the enzyme, showing potential value for applications in anti-inflammatory and anti-tumor research[1].

CAS Number

156728-18-6

UNSPSC

12352005

Target

Elastase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/l-684248.html

Smiles

O=C(O)C1=CC=C(O[C@@H](C2(C)C)N(C(N[C@@H](C3=CC=C(C)C=C3)CCC)=O)C2=O)C=C1

Molecular Formula

C24H28N2O5

Molecular Weight

424.49

References & Citations

[1]Underwood DJ, et al. Mechanism of inhibition of human leucocyte elastase by beta-lactams. 3. Use of electrospray ionization mass spectrometry and two-dimensional NMR techniques to identify beta-lactam-derived E-I complexes. Biochemistry. 1995 Nov 7;34 (44) :14344-55.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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L 684248

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