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BVB808

CAT: 0804-HY-120604Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-120604Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BVB808 (NVP_BVB808) is a selective JAK2 inhibitor with approximately 10-fold selectivity for JAK2 over other JAK family members (such as JAK1, JAK3 or TYK2) in vitro. BVB808 inhibits the activity of JAK2 and reduces the phosphorylation of STAT5, thereby blocking the JAK2-dependent cell proliferation and survival signaling pathways. BVB808 can be used in cancer research[1].
CAS Number
1414587-22-6
Product Name Alternative
NVP_BVB808
UNSPSC
12352005
Target
JAK; STAT
Type
Reference compound
Related Pathways
Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bvb808.html
Smiles
FC(C=C1N2C3=NC(NC4=CC=C(N5C[C@@H](N[C@@H](C5)C)C)C=C4)=NC=C3C=C2)=C(C(F)=C1)CN6CCOCC6
Molecular Formula
C29H33F2N7O
Molecular Weight
533.62
References & Citations
[1]Weigert, et al. "Genetic resistance to JAK2 enzymatic inhibitors is overcome by HSP90 inhibition." The Journal of experimental medicine 209.2 (2012) : 259.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Alternative Products

CatalogName
T89180-01BVB808

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