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AFG206

CAT: 0804-HY-126920Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-126920Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AFG206 is a first-generation ATP competitive “type II” FLT3 inhibitor. AFG206 potently inhibits cell proliferation (IC50 around 0.1 µM) via induction of Apoptosis in FLT3-ITD-Ba/F3 cells and D835Y-Ba/F3 cells. AFG206 is promising for research of acute myeloid leukemia[1].
CAS Number
630122-37-1
UNSPSC
12352005
Target
Apoptosis; FLT3
Type
Reference compound
Related Pathways
Apoptosis; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/afg206.html
Smiles
O=C(NC1=CC=C(CC)C=C1)NC2=CC=C(C=C2)OC3=CC=NC=C3
Molecular Formula
C20H19N3O2
Molecular Weight
333.38
References & Citations
[1]Weisberg E, et al. Antileukemic Effects of Novel First- and Second-Generation FLT3 Inhibitors: Structure-Affinity Comparison. Genes Cancer. 2010 Oct;1 (10) :1021-32.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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