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Raleukin

CAT: 0804-HY-108841-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-108841-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Raleukin (AMG-719) is a recombinant, nonglycosylated human interleukin-1 receptor (IL-1R) antagonist. Raleukin significantly reduces neutrophil accumulation in blood vessels and brain infarct volume as well as improves motor coordination performance in ischemic stroke mice model. Anakinra can be used to study chronic inflammatory disorders like rheumatoid arthritis and cardiovascular recurrence post-myocardial infarction[1][2][3].
CAS Number
143090-92-0
Product Name Alternative
Kineret; Anakinra
UNSPSC
12352203
Target
Interleukin Related
Type
Inhibitory Antibodies
Related Pathways
Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/anakinra.html
Purity
99.40
Solubility
DMSO : < 1 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
[Raleukin]
Molecular Formula
C759H1186N208O232S10
Molecular Weight
(17.3 kDa)
References & Citations
[1]Cvetkovic RS, et al. Anakinra. BioDrugs. 2002;16 (4) :303-11; discussion 313-4.|[2]McCall M, et al. Anakinra potentiates the protective effects of etanercept in transplantation of marginal mass human islets in immunodeficient mice. Am J Transplant. 2012 Feb;12 (2) :322-9.|[3]Harnack U, et al. IL-1 receptor antagonist anakinra enhances tumour growth inhibition in mice receiving peptide vaccination and beta- (1-3), (1-6) -D-glucan. Anticancer Res. 2010 Oct;30 (10) :3959-65.|[4]Huang X, et al. Microglial IL-1RA ameliorates brain injury after ischemic stroke by inhibiting astrocytic CXCL1-mediated neutrophil recruitment and microvessel occlusion. Glia. 2023 Jul;71 (7) :1607-1625.
Shipping Conditions
Isolate blue ice and the product with bubble pack to avoid direct contact
Storage Conditions
Store at 4°C for 2 years, do not freeze
Scientific Category
Inhibitory Antibodies
Clinical Information
Launched
Isoform
IL-1

Alternative Products

CatalogName
P2010-10Raleukin
A24323-50Raleukin (AMG-719) 50mg
A24323-5Raleukin (AMG-719) 5mg
A24323-1Raleukin (AMG-719) 1mg
A24323-10Raleukin (AMG-719) 10mg

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