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Oxatomide

CAT: 0804-HY-123205-04Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-123205-04Size:25 mg
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Description
Oxatomide (KW-4354) is an orally active dual antagonist of the H1-histamine receptor and the P2X7 receptor, as well as an inhibitor of serotonin. Oxatomide possesses antihistaminic, antiallergic and anti-inflammatory activities. Oxatomide can be used in the research of allergic diseases[1][2][3][4].
CAS Number
60607-34-3
Product Name Alternative
KW-4354
UNSPSC
12352005
Hazard Statement
H302
Target
5-HT Receptor; Apoptosis; COX; Histamine Receptor; P2X Receptor; p38 MAPK; PERK
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; GPCR/G Protein; Immunology/Inflammation; MAPK/ERK Pathway; Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/oxatomide.html
Purity
98.11
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C1NC2=CC=CC=C2N1CCCN3CCN(C(C4=CC=CC=C4)C5=CC=CC=C5)CC3
Molecular Formula
C27H30N4O
Molecular Weight
426.55
Precautions
H302
References & Citations
[1] Kazuki Yoshida, et al. P2X7 receptor antagonist activity of the anti-allergic agent oxatomide. Eur J Pharmacol. 2015 Nov 15;767:41-51.|[2]Tanaka T, et al. Effect of oxatomide on otitis media with effusion--an experimental study. Acta Otolaryngol. 1995 Jul;115 (4) :532-8.|[3]Domae M, et al. The antiallergic drug oxatomide promotes human eosinophil apoptosis and suppresses IL-5-induced eosinophil survival. J Allergy Clin Immunol. 2003 Mar;111 (3) :567-72.|[4]Patella V, et al. Oxatomide inhibits the release of proinflammatory mediators from human basophils and mast cells. Int Arch Allergy Immunol. 1996 Sep;111 (1) :23-9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
COX-2; H1 Receptor; MUC4; P2X7 Receptor

Chemical Information

Oxatomide

Oxatomide is a member of the class of benzimidazoles that is 1,3-dihydro-2H-benzimidazol-2-one substituted by a 3-[4-(diphenylmethyl)piperazin-1-yl]propyl group at position 1. It is an anti-allergic drug. It has a role as a geroprotector, a H1-receptor antagonist, a serotonergic antagonist, an anti-allergic agent and an anti-inflammatory agent. It is a member of benzimidazoles, a N-alkylpiperazine and a diarylmethane.

CAS Number60607-34-3
PubChem CID4615
IUPAC Name3-[3-(4-benzhydrylpiperazin-1-yl)propyl]-1H-benzimidazol-2-one
Molecular FormulaC27H30N4O
Molecular Weight426.6
XLogP4.1
Topological Polar Surface Area38.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count7
Heavy Atom Count32
Formal Charge0
Complexity574
SMILES
C1CN(CCN1CCCN2C3=CC=CC=C3NC2=O)C(C4=CC=CC=C4)C5=CC=CC=C5
InChI
InChI=1S/C27H30N4O/c32-27-28-24-14-7-8-15-25(24)31(27)17-9-16-29-18-20-30(21-19-29)26(22-10-3-1-4-11-22)23-12-5-2-6-13-23/h1-8,10-15,26H,9,16-21H2,(H,28,32)
InChIKey
BAINIUMDFURPJM-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Oxatomide
CAS: 60607-34-3
CID: 4615
Formula: C27H30N4O
MW: 426.6
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight426.6
XLogP34.1
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count7
Exact Mass426.24196159
Monoisotopic Mass426.24196159
Topological Polar Surface Area38.8 Ų
Heavy Atom Count32
Formal Charge0
Complexity574
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
286081-01Oxatomide
GTR19231950-01Oxatomide-HCl
CS-O-63535N-Nitroso oxatomide
CS-O-63536N-Nitroso oxatomide Impurity 1
MBS6062767-01Oxatomide (1-[3-[4-(Diphenylmethyl)-1-piperazinyl]propyl]-1,3-dihydro-2H-benzimidazol-2-one,R-35443, Celtect, Cobiona, Dasten, Tinset)
O8107Oxatomide (1-[3-[4- (Diphenylmethyl) -1-piperazinyl]propyl]-1,3-dihydro-2H-benzimidazol-2-one, _x000B_R-35443, Celtect, Cobiona, Dasten, Tinset)

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