Steffimycin B

• Description :

  Steffimycin B is an anthracycline bacterial metabolite originally isolated from Streptomyces. It binds to DNA, preferentially intercalating at sites containing cytosine and guanine.2 Steffimycin B is cytotoxic to MCF-7, KB, NCI-H187, and Vero cells (IC50s=3.5, 6.75, 3.28, and 10.5 μM, respectively) . It is active against M. tuberculosis (MIC=5.2 nM), B. cereus (MIC=1.56 μg/mL), and P. falciparum (IC50=2.19 μM) .

• Product Name Alternative :

  NSC 204855; U 40615

• UNSPSC :

  12352005

• Target :

  Bacterial

• Type :

  Natural Products

• Related Pathways :

  Anti-infection

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Infection

• Assay Protocol :

  https://www.medchemexpress.com/steffimycin-b.html

• Smiles :

  OC1=C(C(C2=C3O)=O)C(C(C2=CC(OC)=C3)=O)=CC(C4=O)=C1[C@H]([C@@H]([C@](O)4C)OC)O[C@H](O[C@H]5C)[C@@H]([C@@H]([C@H]5OC)O)OC

• Molecular Formula :

  C29H32O13

• Molecular Weight :

  588.56

• References & Citations :

  [1]Trenado-Uribe, et al. Antimycobacterial activity of an anthracycline produced by an endophyte isolated from Amphipterygium adstringens. Mol. Biol. Rep. 45 (6), 2563-2570 (2018) .

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• CAS Number :

  [54526-94-2]