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NPD4928

CAT: 0804-HY-167888-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-167888-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
NPD4928, a GPX4 inhibitor, enhances RSL3 -dependent ferroptosis. NPD4928 binds to ferroptosis suppressor protein 1 (FSP1) and inhibits its enzymatic activity[1].
CAS Number
956965-61-0
UNSPSC
12352005
Target
Ferroptosis; Glutathione Peroxidase
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/npd4928.html
Purity
99.48
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1OC2=C(C(C)=C1C)C(OCC(NCCC3=CNC4=C3C=C(OC)C=C4)=O)=CC5=C2CCC(C)(C)O5
Molecular Formula
C29H32N2O6
Molecular Weight
504.57
References & Citations
[1]Hiromasa Yoshioka, et al. Identification of a Small Molecule That Enhances Ferroptosis via Inhibition of Ferroptosis Suppressor Protein 1 (FSP1) . ACS Chem Biol. 2022 Feb 18;17 (2) :483-491.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
GPX4

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