Betahistine

• Description:

  Betahistine is an orally active histamine H1 receptor agonist and a H3 receptor antagonist[1]. Betahistine is used for the study of rheumatoid arthritis (RA) [3].

• UNSPSC:

  12352005

• Hazard Statement:

  H315, H319, H335

• Target:

  Histamine Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Cancer; Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/betahistine.html

• Concentration:

  10mM

• Purity:

  99.84

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  CNCCC1=NC=CC=C1

• Molecular Formula:

  C8H12N2

• Molecular Weight:

  136.19

• Precautions:

  H315, H319, H335

• References & Citations:

  [1]Poyurovsky M, et al. The effect of betahistine, a histamine H1 receptor agonist/H3 antagonist, on olanzapine-induced weight gain in first-episode schizophrenia patients. Int Clin Psychopharmacol. 2005 Mar;20 (2) :101-3.|[2]Gbahou F, et al. Effects of betahistine at histamine H3 receptors: mixed inverse agonism/agonism in vitro and partial inverse agonism in vivo.J Pharmacol Exp Ther. 2010 Sep 1;334 (3) :945-54.|[3]Tang KT, et al. Betahistine attenuates murine collagen-induced arthritis by suppressing both inflammatory and Th17 cell responses.Int Immunopharmacol. 2016 Oct;39:236-245.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Launched

• Isoform:

  H1 Receptor; H3 Receptor

• Citation 01:

  Pharm Res. 2025 Aug;42 (8) :1315-1329.|Brain Sci. 2025 Aug 25.

• CAS Number:

  [5638-76-6]