Diosgenin

CAT: 0804-HY-N0177-01Size: 100 mgDry Ice: NoHazardous: No
CAT#:0804-HY-N0177-01Size:100 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
Diosgenin, a steroidal saponin, can inhibit STAT3 signaling pathway[1]. Diosgenin is an exogenous activator of Pdia3/ERp57[2]. Diosgenin inhibits aortic atherosclerosis progression by suppressing macrophage miR-19b expression[5].
CAS Number
[512-04-9]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
MicroRNA; STAT
Type
Natural Products
Related Pathways
Epigenetics; JAK/STAT Signaling; Stem Cell/Wnt
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/Diosgenin.html
Purity
99.92
Solubility
DMSO : < 1 mg/mL|Ethanol : 3.33 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O[C@]1([H])CC2=CC[C@]3([H])[C@@](CC[C@@]4(C)[C@@]3([H])C[C@@]5([H])[C@]4([H])[C@@](C)([H])[C@@]6(CC[C@@]([H])(C)CO6)O5)([H])[C@@]2(C)CC1
Molecular Formula
C27H42O3
Molecular Weight
414.62
Precautions
H302, H315, H319, H335
References & Citations
[1]Jeremy E. Chojnacki, et al. Bivalent ligands incorporating curcumin and diosgenin as multifunctional compounds against Alzheimer’s disease. Bioorganic & Medicinal Chemistry, 23 (2015) 7324–7331|[2]Li F, et al. Diosgenin, a steroidal saponin, inhibits STAT3 signaling pathway leading to suppression of proliferation and chemosensitization of human hepatocellular carcinoma cells. Cancer Lett. 2010 Jun 28;292 (2) :197-207.|[3]Wang X, et al. Effect of diosgenin on metabolic dysfunction: Role of ERβ in the regulation of PPARγ. Toxicol Appl Pharmacol. 2015 Dec 1;289 (2) :286-96.|[4]Tohda C, et al. Diosgenin is an exogenous activator of 1,25D₃-MARRS/Pdia3/ERp57 and improves Alzheimer's disease pathologies in 5XFAD mice. Sci Rep. 2012;2:535.|[5]Yun-cheng Lv, et al. Diosgenin Inhibits Atherosclerosis via Suppressing the MiR-19b-induced Downregulation of ATP-binding Cassette Transporter A1. Atherosclerosis, 2014, 240 (1), 80-89.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
STAT3

Related Products

CatalogName
HY-N0125-01Diosmetin
HY-N0125SDiosmetin-d3
HY-N0125R-01Diosmetin (Standard)
HY-W401407-01Diosmetin-3-O-glucuronide
HY-142258SDiosmetin-3-O-glucuronide-d3
HY-W769530Diosmetin 3',7-diglucuronide-d3
HY-N0713-01Diosmetin-7-O-β-D-glucopyranoside
HY-N6879-01DiosMetin 7-O-β-D-Glucuronide
HY-N6879RDiosMetin 7-O-β-D-Glucuronide (Standard)
HY-N12951Diosmetin 6,8-di-C-glucoside

Alternative Products

CatalogName
14538-5Diosgenin

Popular Products