Goitrin

• Description:

  Goitrin ((S) -Goitrin), a product of glucosinolate-myrosinase reactions, is a potent inhibitor of thyroid peroxidase. Goitrin can inhibit iodine utilization by the thyroid. Goitrin also exhibits anti-influenza virus (H1N1) activity[1][2][3].

• Product Name Alternative:

  (S) -Goitrin; L-5-Vinyl-2-thiooxazolidone

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319

• Target:

  Influenza Virus

• Type:

  Natural Products

• Related Pathways:

  Anti-infection

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/goitrin.html

• Purity:

  99.66

• Solubility:

  10 mM in DMSO

• Smiles:

  S=C1O[C@@H](C=C)CN1

• Molecular Formula:

  C5H7NOS

• Molecular Weight:

  129.18

• Precautions:

  H302, H315, H319

• References & Citations:

  [1]Felker P, et, al. Concentrations of thiocyanate and goitrin in human plasma, their precursor concentrations in brassica vegetables, and associated potential risk for hypothyroidism. Nutr Rev. 2016 Apr;74 (4) :248-58.|[2]Wooding S, et, al. Genetics and bitter taste responses to goitrin, a plant toxin found in vegetables. Chem Senses. 2010 Oct;35 (8) :685-92.|[3]Nie LX, et, al. Antiviral activity of Isatidis Radix derived glucosinolate isomers and their breakdown products against influenza A in vitro/ovo and mechanism of action. J Ethnopharmacol. 2020 Apr 6;251:112550.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture and light)

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• CAS Number:

  [500-12-9]