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Mesembrine

CAT: 0804-HY-121162-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-121162-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Mesembrine ((+) -Mesembrine) a main alkaloid that features an aryloctahydroindole skeleton. Mesembrine is a 5-HT transporter inhibitor with a Ki of 1.4 nM. Mesembrine also inhibits phosphodiesterase 4B (PDE4B) with an IC50 of 7.8 μM[1][2].
CAS Number
468-53-1
Product Name Alternative
(+) -Mesembrine
UNSPSC
12352005
Target
5-HT Receptor; Phosphodiesterase (PDE)
Type
Natural Products
Related Pathways
GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/mesembrine.html
Solubility
10 mM in DMSO
Smiles
O=C1CC[C@]2(C3=CC=C(OC)C(OC)=C3)CCN(C)[C@]2([H])C1
Molecular Formula
C17H23NO3
Molecular Weight
289.37
References & Citations
[1]John L Krstenansky. Mesembrine alkaloids: Review of their occurrence, chemistry, and pharmacology. J Ethnopharmacol. 2017 Jan 4;195:10-19.|[2]Golo M J Meyer, et al. GC-MS, LC-MS (n), LC-high resolution-MS (n), and NMR studies on the metabolism and toxicological detection of mesembrine and mesembrenone, the main alkaloids of the legal high "Kanna" isolated from Sceletium tortuosum. Anal Bioanal Chem. 2015 Jan;407 (3) :761-78.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
MUC4; PDE4

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